Human Papillomaviruses in Head and Neck Cancer
HPV-associated squamous cell carcinomas of the head and neck are a subgroup of tumors that can be defined as a specific tumor entity. Socioepidemiological, biomolecular, and biological data describe significant differences in HPV-infected and noninfected patients giving rise to this opinion.
Head and neck squamous cell carcinoma (HNSCC) arises in the oral cavity, oropharynx, larynx, or hypopharynx and is the sixth leading cancer incidence worldwide representing an estimated 5 % of all cancers. It is likely that approximately 570,000 cases will arise each year worldwide and that only 40–50 % of patients will survive for 5 years. Besides tobacco and alcohol consumption, the etiological involvement of human papillomaviruses (HPV), specifically HPV genotype 16, in the carcinogenesis of HNSCC has proven to be of significant importance in both initiation and progression of these tumors. Starting from first reports showing that HPV plays a role not only...
KeywordsTonsillar Carcinoma Cell Cycle Life p16INK4A Overexpression Specific Tumor Entity Anatomical Tumor Site
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