Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Ramachandran Rashmi
  • Julie K. Schwarz
  • Sreeraj G. Pillai
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7147-6


FDG-PET is a three-dimensional clinical imaging tool used in medical oncology for detection, staging, restaging, and monitoring of therapy response of cancer with the glucose analog tracer 2-[fluorine-18] fluoro-2-deoxy-D-glucose (FDG).



FDG-PET is based on the famous Warburg effect. Tumor cells depend on glycolysis for energy support even under aerobic conditions, i.e., tumor cells take up glucose at a higher rate than their normal counterparts. Positron emission tomography (PET) is a noninvasive imaging technique that localizes the accumulation of 18-fluorine (18F)-labeled glucose within the body. This is done through a tomographic technique that computes the three-dimensional location of radioactivity based on annihilation photons that are emitted during b-positive decay of 18F. FDG-PET allows quantitative assessment of glucose uptake. The accumulation of FDG in tissue is directly proportional to the amount of glucose utilization. Images are...


Positron Emission Tomography Standardize Uptake Volume Positron Emission Tomography Image Attenuation Correction Filter Back Projection 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Ramachandran Rashmi
    • 1
  • Julie K. Schwarz
    • 1
  • Sreeraj G. Pillai
    • 2
  1. 1.Department of Radiation OncologyWashington University School of MedicineSt. LouisUSA
  2. 2.Department of SurgeryWashington University School of MedicineSt. LouisUSA