Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

FDG-PET

  • Ramachandran Rashmi
  • Julie K. Schwarz
  • Sreeraj G. Pillai
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7147-6

Definition

FDG-PET is a three-dimensional clinical imaging tool used in medical oncology for detection, staging, restaging, and monitoring of therapy response of cancer with the glucose analog tracer 2-[fluorine-18] fluoro-2-deoxy-D-glucose (FDG).

Characteristics

Principle

FDG-PET is based on the famous Warburg effect. Tumor cells depend on glycolysis for energy support even under aerobic conditions, i.e., tumor cells take up glucose at a higher rate than their normal counterparts. Positron emission tomography (PET) is a noninvasive imaging technique that localizes the accumulation of 18-fluorine (18F)-labeled glucose within the body. This is done through a tomographic technique that computes the three-dimensional location of radioactivity based on annihilation photons that are emitted during b-positive decay of 18F. FDG-PET allows quantitative assessment of glucose uptake. The accumulation of FDG in tissue is directly proportional to the amount of glucose utilization. Images are...

Keywords

Positron Emission Tomography Standardize Uptake Volume Positron Emission Tomography Image Attenuation Correction Filter Back Projection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Delbeke D (1999) Oncological applications of FDG PET imaging: brain tumors, colorectal cancer lymphoma and melanoma. J Nucl Med 40(4):591–603PubMedGoogle Scholar
  2. Kelloff GJ, Hoffman JM, Johnson B et al (2005) Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug development. Clin Cancer Res 11:2785–2808CrossRefPubMedGoogle Scholar
  3. Schwarz JK, Grigsby PW, Dehdashti F, Delbeke D (2009) The role of 18F-FDG PET in assessing therapy response in cancer of the cervix and ovaries. J Nucl Med 50(Suppl 1):64S–73SCrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Ramachandran Rashmi
    • 1
  • Julie K. Schwarz
    • 1
  • Sreeraj G. Pillai
    • 2
  1. 1.Department of Radiation OncologyWashington University School of MedicineSt. LouisUSA
  2. 2.Department of SurgeryWashington University School of MedicineSt. LouisUSA