FDG-PET is a three-dimensional clinical imaging tool used in medical oncology for detection, staging, restaging, and monitoring of therapy response of cancer with the glucose analog tracer 2-[fluorine-18] fluoro-2-deoxy-D-glucose (FDG).
FDG-PET is based on the famous Warburg effect. Tumor cells depend on glycolysis for energy support even under aerobic conditions, i.e., tumor cells take up glucose at a higher rate than their normal counterparts. Positron emission tomography (PET) is a noninvasive imaging technique that localizes the accumulation of 18-fluorine (18F)-labeled glucose within the body. This is done through a tomographic technique that computes the three-dimensional location of radioactivity based on annihilation photons that are emitted during b-positive decay of 18F. FDG-PET allows quantitative assessment of glucose uptake. The accumulation of FDG in tissue is directly proportional to the amount of glucose utilization. Images are...