Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

PDT-Induced Apoptosis

  • N. K. Mak
  • Maria Li Lung
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7145-3



The process of programmed cell death is triggered through the photoactivation of photosensitizers in the target cells. Photosensitizers that induce tumor cell apoptosis are usually localized in organelles such as mitochondria, lysosomes, and endoplasmic reticulum.


Apoptosis is a highly regulated cell death process executed by a family of caspases. Two well-established pathways, namely, extrinsic and intrinsic apoptotic pathways, have been described. The extrinsic pathway involves the initial binding of ligands to the cell surface death receptors and the subsequent activation of initiator caspase-8. The intrinsic pathway involves the convergence of stress signals to the mitochondria, leading to mitochondria membrane permeabilization (MOMP), releasing of proapoptotic proteins such as cytochrome C into the cytosol, and the activation of initiator caspase-9. Apoptotic signals from these two activation pathways...


Golgi Complex Cell Death Process Lysosomal Membrane Permeabilization Proapoptotic Signal Cell Surface Death Receptor 
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  1. Ali-Seyed M, Bhuvaneswari R, Soo KC, Olivo M (2011) Photolon™ – photosensitization induces apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes. Int J Oncol 39(4):821–831PubMedGoogle Scholar
  2. Liu L, Zhang Z, Xing D (2011) Cell death via mitochondrial apoptotic pathway due to activation of Bax by lysosomal photodamage. Free Radic Biol Med 51(1):53–68CrossRefPubMedGoogle Scholar
  3. Oleinick NL, Morris RL, Belichenko I (2002) The role of apoptosis in response to photodynamic therapy: what, where, why, and how. Photochem Photobiol Sci 1(1):1–21CrossRefPubMedGoogle Scholar
  4. Peng TI, Chang CJ, Guo MJ, Wang YH, Yu JS, Wu HY, Jou MJ (2005) Mitochondrion-targeted photosensitizer enhances the photodynamic effect-induced mitochondrial dysfunction and apoptosis. Ann N Y Acad Sci 1042:419–428CrossRefPubMedGoogle Scholar
  5. Starkey JR, Rebane AK, Drobizhev MA, Meng F, Gong A, Elliott A, McInnerney K, Spangler CW (2008) New two-photon activated photodynamic therapy sensitizers induce xenograft tumor regressions after near-IR laser treatment through the body of the host mouse. Clin Cancer Res 14(20):6564–6573CrossRefPubMedGoogle Scholar

See Also

  1. Yoo JO, Ha KS (2012) New insights into the mechanisms for photodynamic therapy-induced cancer cell death. Int Rev Cell Mol Biol. 295:139–174Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of BiologyHong Kong Baptist UniversityKowloon Tong, Hong KongChina
  2. 2.Department of Clinical Oncology, Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina