NDRG2 stands for N-myc downstream-regulated gene 2, which was originally cloned by polymerase chain reaction-based subtractive hybridization from glioblastoma, using normal brain tissues as control. NDRG2 is located at chromosome arm 14q11.2 and is a gene that is significantly suppressed in glioblastoma tissues. Ndrg2 protein expression was observed in many developing tissues and organs including the heart, brain, lung, gut, liver, kidney, skeletal muscle, cartilage, chorion, epidermis, and whisker follicles. Ndrg2 expression was also observed in a variety of adult tissues, particularly in the heart and brain. NDRG2 gene expression decreased in different cancer tissues, such as breast cancer, liver cancer, gastric cancer, oligodendroglial tumors, and skin cancer. NDRG2 is a candidate tumor suppressor gene and may be a useful and functionally relevant biomarker for predicting aggressive forms of cancer. Ndrg2 protein contains several...
KeywordsOligodendroglial Tumor Candidate Tumor Suppressor Gene Intracellular Signal Transduction Pathway NDRG2 Expression Ndrg2 Protein
- Cole MD (1986) The myc oncogene: its role in transformation and differentiation. Annu Rev Genet 20:361–384Google Scholar
- Dang CV (1991) c-myc oncoprotein function. Biochim Biophys Acta 1072:103–113Google Scholar
- Deng YC, Yao LB, Liu XP et al (2001) Exploring a new gene containing ACP like domain in human brain and expression it in E. coli. Prog Biochem Biophys 28:72–76Google Scholar
- Fridman JS and Lowe SW (2003) Control of apoptosis by p53. Oncogene 22: 9030–9040Google Scholar
- Melotte V, Qu XH, Ongenaert M et al (2010) The N-myc downstream regulated gene (NDRG) family:diverse functions, multiple applications The FASEB Journal 24:4153–4166Google Scholar
- Vogelstein B, Lane D, and Levine AJ (2000) Surfing the p53 network. Nature 408:307–310Google Scholar