Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

NGRD2

  • Libo Yao
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7144-7

Synonyms

Definition

NDRG2 stands for N-myc downstream-regulated gene 2, which was originally cloned by polymerase chain reaction-based subtractive hybridization from glioblastoma, using normal brain tissues as control. NDRG2 is located at chromosome arm 14q11.2 and is a gene that is significantly suppressed in glioblastoma tissues. Ndrg2 protein expression was observed in many developing tissues and organs including the heart, brain, lung, gut, liver, kidney, skeletal muscle, cartilage, chorion, epidermis, and whisker follicles. Ndrg2 expression was also observed in a variety of adult tissues, particularly in the heart and brain. NDRG2 gene expression decreased in different cancer tissues, such as breast cancer, liver cancer, gastric cancer, oligodendroglial tumors, and skin cancer. NDRG2 is a candidate tumor suppressor gene and may be a useful and functionally relevant biomarker for predicting aggressive forms of cancer. Ndrg2 protein contains several...

Keywords

Oligodendroglial Tumor Candidate Tumor Suppressor Gene Intracellular Signal Transduction Pathway NDRG2 Expression Ndrg2 Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular BiologyThe Fourth Military Medical UniversityXi’anChina