Living reference work entry
PICALM is a ubiquitously expressed 660-amino-acid protein. PICALM localizes predominantly to the cytoplasm where it is involved in clathrin-mediated endocytosis. Structurally, PICALM contains several domains important for endocytosis, including an ENTH domain, DPF and NPF motifs, and a clathrin-binding domain (Fig. 1). PICALM has been identified in leukemic chromosomal translocations with AF10 and MLL, encoding for fusion genes CALM- AF10 and MLL- CALM, respectively (Fig. 1).
KeywordsAcute Myeloid Leukemia Alzheimer Disease Amyloid Precursor Protein Amyloid Plaque Bone Marrow Transplantation Model
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