Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

PICALM

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7143-3

Synonyms

Definition

PICALM is a ubiquitously expressed 660-amino-acid protein. PICALM localizes predominantly to the cytoplasm where it is involved in clathrin-mediated endocytosis. Structurally, PICALM contains several domains important for endocytosis, including an ENTH domain, DPF and NPF motifs, and a clathrin-binding domain (Fig. 1). PICALM has been identified in leukemic chromosomal translocations with AF10 and MLL, encoding for fusion genes CALM- AF10 and MLL- CALM, respectively (Fig. 1).

Keywords

Acute Myeloid Leukemia Alzheimer Disease Amyloid Precursor Protein Amyloid Plaque Bone Marrow Transplantation Model 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access

References

  1. Dreyling MH et al (1996) The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family. Proc Natl Acad Sci U S A 93(10):4804–4809PubMedPubMedCentralCrossRefGoogle Scholar
  2. Harold D et al (2009) Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease. Nat Genet 41:1088–1093PubMedPubMedCentralCrossRefGoogle Scholar
  3. Klebig ML et al (2003) Mutations in the clathrin-assembly gene Picalm are responsible for the hematopoietic and iron metabolism abnormalities in fit1 mice. Proc Natl Acad Sci U S A 100(14):8360–8365PubMedPubMedCentralCrossRefGoogle Scholar
  4. Okada Y et al (2006) Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L. Nat Cell Biol 9:1017–1024CrossRefGoogle Scholar
  5. Scotland PB et al (2012) The PICALM protein plays a key role in iron homeostasis and cell proliferation. PLoS One 7(8):e44252PubMedPubMedCentralCrossRefGoogle Scholar
  6. Suzuki M et al (2012) The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice. PLoS One 7(2):e31854PubMedPubMedCentralCrossRefGoogle Scholar
  7. Tebar F et al (1999) Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic. Mol Biol Cell 10:2687–2702PubMedPubMedCentralCrossRefGoogle Scholar
  8. Xiao Q et al (2012) Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis. J Biol Chem 287(25):21279–21289PubMedPubMedCentralCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Pediatric Hematology-OncologyDuke University Medical CenterDurhamUSA
  2. 2.Molecular Cancer BiologyDuke University Medical CenterDurhamUSA