Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Daniel S. Wechsler
  • Amanda E. Conway
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7143-3



PICALM is a ubiquitously expressed 660-amino-acid protein. PICALM localizes predominantly to the cytoplasm where it is involved in clathrin-mediated endocytosis. Structurally, PICALM contains several domains important for endocytosis, including an ENTH domain, DPF and NPF motifs, and a clathrin-binding domain (Fig. 1). PICALM has been identified in leukemic chromosomal translocations with AF10 and MLL, encoding for fusion genes CALM- AF10 and MLL- CALM, respectively (Fig. 1).


Acute Myeloid Leukemia Alzheimer Disease Amyloid Precursor Protein Amyloid Plaque Bone Marrow Transplantation Model 
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  1. Dreyling MH et al (1996) The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family. Proc Natl Acad Sci U S A 93(10):4804–4809PubMedPubMedCentralCrossRefGoogle Scholar
  2. Harold D et al (2009) Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease. Nat Genet 41:1088–1093PubMedPubMedCentralCrossRefGoogle Scholar
  3. Klebig ML et al (2003) Mutations in the clathrin-assembly gene Picalm are responsible for the hematopoietic and iron metabolism abnormalities in fit1 mice. Proc Natl Acad Sci U S A 100(14):8360–8365PubMedPubMedCentralCrossRefGoogle Scholar
  4. Okada Y et al (2006) Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L. Nat Cell Biol 9:1017–1024CrossRefGoogle Scholar
  5. Scotland PB et al (2012) The PICALM protein plays a key role in iron homeostasis and cell proliferation. PLoS One 7(8):e44252PubMedPubMedCentralCrossRefGoogle Scholar
  6. Suzuki M et al (2012) The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice. PLoS One 7(2):e31854PubMedPubMedCentralCrossRefGoogle Scholar
  7. Tebar F et al (1999) Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic. Mol Biol Cell 10:2687–2702PubMedPubMedCentralCrossRefGoogle Scholar
  8. Xiao Q et al (2012) Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis. J Biol Chem 287(25):21279–21289PubMedPubMedCentralCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Pediatric Hematology-OncologyDuke University Medical CenterDurhamUSA
  2. 2.Molecular Cancer BiologyDuke University Medical CenterDurhamUSA