Definition
The PIM protein kinase family (PIMs) consists of three members (PIM-1, PIM-2, and PIM-3), with PIM-1 and PIM-2 having two and three isoforms, respectively, due to the use of alternative translation initiation sites. Their name is derived from the identification of its founding member pim-1 as a gene frequently activated by Moloney murine leukemia virus in T-cell lymphomas (proviral integration of Moloney virus).
Characteristics
Regulation of Expression and Activity
PIMs are serine/threonine kinases that have been shown to be dispensable for embryonic development, survival, or fertility, as mice deficient in all three PIM kinases are viable, although they display a significant reduction in body size, indicating that PIM kinases are important for growth. All three PIM kinases share significant (60–70 %) homology and have several common substrates; however, several targets that are unique to specific PIM family members, as in case...
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References
Brault L, Gasser C, Bracher F, Huber K, Knapp S et al (2010) PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers. Haematologica 95:1004–1015
Drygin D, Haddach M, Pierre F, Ryckman DM (2012) Potential use of selective and nonselective Pim kinase inhibitors for cancer therapy. J Med Chem 55:8199–8208
Isaac M, Siu A, Jongstra J (2011) The oncogenic PIM kinase family regulates drug resistance through multiple mechanisms. Drug Resist Updat 14:203–211
Morwick T (2010) Pim kinase inhibitors: a survey of the patent literature. Expert Opin Ther Pat 20:193–212
Nawijn MC, Alendar A, Berns A (2011) For better or for worse: the role of Pim oncogenes in tumorigenesis. Nat Rev Cancer 11:23–34
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Drygin, D. (2014). PIM Protein Kinase Family. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_7141-4
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DOI: https://doi.org/10.1007/978-3-642-27841-9_7141-4
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Publisher Name: Springer, Berlin, Heidelberg
Online ISBN: 978-3-642-27841-9
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