PIM Protein Kinase Family
The PIM protein kinase family (PIMs) consists of three members (PIM-1, PIM-2, and PIM-3), with PIM-1 and PIM-2 having two and three isoforms, respectively, due to the use of alternative translation initiation sites. Their name is derived from the identification of its founding member pim-1 as a gene frequently activated by Moloney murine leukemia virus in T-cell lymphomas (proviral integration of Moloney virus).
Regulation of Expression and Activity
PIMs are serine/threonine kinases that have been shown to be dispensable for embryonic development, survival, or fertility, as mice deficient in all three PIM kinases are viable, although they display a significant reduction in body size, indicating that PIM kinases are important for growth. All three PIM kinases share significant (60–70 %) homology and have several common substrates; however, several targets that are unique to specific PIM family members, as in case...