Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

UTX

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7137-3

Synonyms

Definition

UTX/KDM6A is a gene located on the X chromosome (Xp11.2) and one of a limited number of genes on the X chromosome that escapes X inactivation in females. The encoded protein is a histone demethylase, i.e., catalyzes the demethylation of di- and trimethylated histone H3. This protein contains a C-terminal catalytic domain, called the Jumonji (JmjC) domain, and an N-terminal domain that contains tetratricopeptide repeats (TPRs) for protein–protein interactions.

Characteristics

Introduction: Chromatin Structure and Epigenetic Modifications

DNA is packed into chromatin in the nucleus of eukaryotic cells. The basic constituent of the chromatin is the nucleosome, which is comprised of 147 base pairs of DNA wound around an octamer of core histone proteins. Posttranslational covalent modifications of the N-terminal tails of histone proteins include methylation,...

Keywords

Esophageal Squamous Cell Carcinoma Histone Demethylase Demethylase Activity Embryonic Ectoderm Development JmjC Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Hübner MR, Spector DL (2010) Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation. Cold Spring Harb Symp Quant Biol 75:43–49CrossRefPubMedGoogle Scholar
  2. Kim E, Song JJ (2011) Diverse ways to be specific: a novel Zn-binding domain confers substrate specificity to UTX/KDM6A histone H3 Lys 27 demethylase. Genes Dev 25:2223–2226CrossRefPubMedPubMedCentralGoogle Scholar
  3. Lunyak VV, Kennedy BK (2011) Aged worms erase epigenetic history. Cell Metab 14:147–148CrossRefPubMedGoogle Scholar
  4. Miller SA, Mohn SE, Weinmann AS (2010) Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. Mol Cell 40:594–605CrossRefPubMedPubMedCentralGoogle Scholar
  5. Swigut T, Wysocka J (2007) H3K27 demethylases, at long last. Cell 131:29–32CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Inserm Unité Mixte de Recherche (UMR) 1009, Institut Gustave RoussyUniversity Paris-Sud 11VillejuifFrance