Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Activation-Induced Cytidine Deaminase

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7136-2

Synonyms

Definition

Activation-induced cytidine deaminase (AID) (EC 3.5.4.5) is a 198-amino acid polypeptide enzyme that is primarily expressed in germinal center (GC) B cells of the secondary lymphoid organs. Its physiological function is to introduce point mutations into the variable and switch regions of immunoglobulin (Ig) genes during the processes of somatic hypermutation (SHM) and class switch recombination (CSR) in GC B cells, respectively, leading to a highly diversified antibody affinity repertoire and alternative use of different constant regions of Ig. Patients with defective AID due to germline mutations develop type 2 hyper-IgM syndrome (HIGM2), a type of immunodeficiency resulting in high levels of serum IgM and lack of other post-switch Ig isotypes. Given its potent mutation-inducing property, deregulated expression of AID in the wrong place or at the wrong time is often associated with various cancers.

Characteristics

Identification of AID

There...

Keywords

Chronic Lymphocytic Leukemia Germinal Center Mantle Cell Lymphoma Base Excision Repair Burkitt Lymphoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of ImmunologyMayo Clinic, College of MedicineRochesterUSA