The CHFR (checkpoint with forkhead and RING finger domains) gene, located at 12q24.33, coordinates mitotic prophase by delaying chromosome condensation in response to a mitotic stress.
Chromosomal segregation at mitosis is preceded by a series of steps, including condensation of chromosome and separation of the centrosome, chromosomal alignment, and sister-chromatid separation (Shibata et al. 2002). To ensure fidelity of the replicated genetic material, mitosis is carefully choreographed and monitored by several checkpoint systems (Nigg 2001; Wassmann and Benezra 2001). Missteps in any one of these processes can result in aneuploidy or genetic instability, setting off any number of deleterious events such as unregulated cell growth, leading to neoplastic transformation and tumor progression. A mitotic...
KeywordsColorectal Adenoma Promoter Hypermethylation Oral Squamous Cell Carcinoma Primary Colorectal Cancer Mitotic Checkpoint
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