Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Inflammosome

  • Fong-Fong Chu
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7129-2

Definition

An inflammasome is an intracellular multiprotein complex that responds to exogenous or endogenous danger or damage signals to activate caspase-1, which promotes secretion of proinflammatory cytokines interleukin (IL)-1β, IL-18, and pyroptosis (a form of phagocyte cell death induced by bacterial pathogens). Different inflammasomes are named after the core protein in the complex; they are NLRP1 inflammasome, NLRP3 inflammasome, NLRP6 inflammasome, NLRC4/IPAF inflammasome, and AIM2 inflammasome. Inflammasomes play major roles in innate immunity by activating an inflammation in response to pathogens but also to self-danger signals.

Characteristics

List of Abbreviations

List of Abbreviations

AIM2

Absent in melanoma-2

ASC

Apoptosis-associated speck-like protein containing a CARD

CIITA

Major histocompatibility class II transcription activator

CARD

Caspase activation and recruitment domain

Caspase

Cysteinyl aspartate protease

DAMPs

Damage-associated molecular patterns

HET-E

A...

Keywords

NLRP3 Inflammasome Lethal Toxin Muramyl Dipeptide Activate NLRP3 Inflammasome Pyrin Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Chen GY, Nunez G (2011) Inflammasomes in intestinal inflammation and cancer. Gastroenterology 141(6):1986–1999CrossRefPubMedPubMedCentralGoogle Scholar
  2. Horvath GL, Schrum JE, De Nardo CM, Latz E (2011) Intracellular sensing of microbes and danger signals by the inflammasomes. Immunol Rev 243(1):119–135CrossRefPubMedPubMedCentralGoogle Scholar
  3. Latz E (2010) The inflammasomes: mechanisms of activation and function. Curr Opin Immunol 22(1):28–33, PMCID: 2844336CrossRefPubMedPubMedCentralGoogle Scholar
  4. Strowig T, Henao-Mejia J, Elinav E, Flavell R (2012) Inflammasomes in health and disease. Nature 481(7381):278–286CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Cancer BiologyBeckman Research Institute of City of HopeDuarteUSA