Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Fong-Fong Chu
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7129-2


An inflammasome is an intracellular multiprotein complex that responds to exogenous or endogenous danger or damage signals to activate caspase-1, which promotes secretion of proinflammatory cytokines interleukin (IL)-1β, IL-18, and pyroptosis (a form of phagocyte cell death induced by bacterial pathogens). Different inflammasomes are named after the core protein in the complex; they are NLRP1 inflammasome, NLRP3 inflammasome, NLRP6 inflammasome, NLRC4/IPAF inflammasome, and AIM2 inflammasome. Inflammasomes play major roles in innate immunity by activating an inflammation in response to pathogens but also to self-danger signals.


List of Abbreviations

List of Abbreviations


Absent in melanoma-2


Apoptosis-associated speck-like protein containing a CARD


Major histocompatibility class II transcription activator


Caspase activation and recruitment domain


Cysteinyl aspartate protease


Damage-associated molecular patterns




NLRP3 Inflammasome Lethal Toxin Muramyl Dipeptide Activate NLRP3 Inflammasome Pyrin Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Cancer BiologyBeckman Research Institute of City of HopeDuarteUSA