Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Resistin

  • Yung-Hsi Kao
  • Ya-Chu Tang
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7127-4

Synonyms

Definition

Resistin is a cysteine-rich peptide hormone that was isolated from adipose tissues and that has been found to link obesity to type II diabetes in rodents. The name resistin stands for “resistance to insulin” because it reduces the sensitivity of target tissues to insulin.

Characteristics

The Discovery

Resistin was discovered by two different groups. The gene homologue of resistin was initially found in normal mouse lung and in human bone marrow. In mice, resistin mRNA is primarily expressed in white adipose tissue in mesentery and adjacent to the thyroid gland and trachea of mice. Because resistin was translated from the third homologue found in the inflammatory zone (FIZZ) gene family, it was originally called FIZZ3. Two additional homologues, FIZZ1 and FIZZ2, were...

Keywords

White Adipose Tissue Resistin Level Extracellularly Regulate Signal Protein Kinase Serum Resistin Level Resistin Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Barnes KM, Miner JL (2009) Role of resistin in insulin sensitivity in rodents and humans. Curr Protein Pept Sci 10:96–107CrossRefPubMedGoogle Scholar
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  5. Koerner A, Kratzsch J, Kiess W (2005) Adipocytokines: leptin-the classical, resistin-the controversial, adiponectin-the promising, and more to come. Best Pract Res Clin Endocrinol Metab 19:525–546CrossRefPubMedGoogle Scholar
  6. Schwartz DR, Lazar MA (2011) Human resistin: found in translation from mouse to man. Trends Endocrinol Metab 22:259–265PubMedCentralPubMedGoogle Scholar
  7. Steppan CM, Balley ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA (2001) The hormone resistin links obesity to diabetes. Nature 409:307–312CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Life Sciences, College of ScienceNational Central UniversityJhongli CityTaiwan