Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Intestinal Alkaline Phosphatase

  • Omeed Moaven
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7126-15


Intestinal alkaline phosphatase (IAP) is a member of the alkaline phosphatase (AP) family, which in humans has four members that are encoded by four different genes.
  • IAP

  • Placental AP

  • Placental-like AP

  • Tissue-nonspecific AP (expressed mainly in the liver, bone, and kidney)

IAP is a membrane-bound glycoprotein enzyme exclusively produced in the small intestine and expressed in villus-associated enterocytes. It catalyzes the hydrolysis of monophosphate esters and transphosphorylation reactions on a wide spectrum of substrates (e.g., phosphatidates with different fatty acyl chains, nucleotides phosphate residues, inorganic phosphate from polyphosphates in diet).



The IAP gene maps to chromosome 2q34–37 along with the loci for placental and placental-like alkaline phosphatase and produces a 528-amino acid protein. It is a homodimeric enzyme, and each monomer contains five cysteine residues and three metal ions (two Zn++ and one Mg++).

Gene Regulation



Sodium Butyrate Intestinal Alkaline Phosphatase Defense Factor Placental Alkaline Phosphatase Intracellular Lipid Droplet 
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See Also

  1. (2012) Histone Acetylation. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1697. doi: 10.1007/978-3-642-16483-5_2750Google Scholar
  2. (2012) Homeobox. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1721. doi: 10.1007/978-3-642-16483-5_2787Google Scholar
  3. (2012) Tumor Necrosis Factor-α. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3800. doi: 10.1007/978-3-642-16483-5_6041Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of SurgeryMassachusetts General Hospital, Harvard Medical SchoolBostonUSA