Dimeric protein complex that enhances biosynthesis of follicle-stimulating hormone (FSH) and secretion from the pituitary.
Activins are members of the TGF-β superfamily of proteins, and in addition to stimulating FSH release from the pituitary they are involved in regulation of a diverse range of physiological processes including embryonic development, reproduction, and fertility, and are implicated in the development and progression of cancers, especially of the testis, ovary, and adrenal gland.
KeywordsMale Infertility Adrenal Tumor Prostate Disease Wasting Syndrome Overt Effect
- Chen YG, Lui HM, Lin SL, Lee JM, Ying SY (2002) Regulation of cell proliferation, apoptosis, and carcinogenesis by activin. Exp Biol Med (Maywood) 227:75–87Google Scholar