Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Activin

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7125-3

Synonyms

Definition

Dimeric protein complex that enhances biosynthesis of follicle-stimulating hormone (FSH) and secretion from the pituitary.

Characteristics

Activins are members of the TGF-β superfamily of proteins, and in addition to stimulating FSH release from the pituitary they are involved in regulation of a diverse range of physiological processes including embryonic development, reproduction, and fertility, and are implicated in the development and progression of cancers, especially of the testis, ovary, and adrenal gland.

There are five known β-subunits (designated β A through β E) that can form homodimers or heterodimers, for example activin A (= β Aβ A), activin B (=β Bβ B), activin C (=β Cβ C), activin AB (=β Aβ B), and activin AC (=β Aβ C, Fig. 1). Two of these subunits (β C and β E) were discovered only in the last decade and we know little about them, mainly...

Keywords

Male Infertility Adrenal Tumor Prostate Disease Wasting Syndrome Overt Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Chen YG, Lui HM, Lin SL, Lee JM, Ying SY (2002) Regulation of cell proliferation, apoptosis, and carcinogenesis by activin. Exp Biol Med (Maywood) 227:75–87Google Scholar
  2. Gold E, Risbridger G (2011) Activins and activin antagonists in the prostate and prostate cancer. Mol Cell Endocrinol. doi:10.1016/j.mce.2011.07.005PubMedGoogle Scholar
  3. Harrison CA, Gray PC, Vale WW, Robertson DM (2005) Antagonists of activin signaling: mechanisms and potential biological applications. Trends Endocrinol Metab 16:73–78CrossRefPubMedGoogle Scholar
  4. Risbridger GP, Schmitt JF, Robertson DR (2001) Activins and inhibins in endocrine and other tumours. Endocr Rev 22:836–858CrossRefPubMedGoogle Scholar
  5. Robertson DM, Burger HG, Fuller PJ (2004) Inhibin/activin and ovarian cancer. Endocr Relat Cancer 11:35–49CrossRefPubMedGoogle Scholar
  6. Stenvers KL, Findlay JK (2010) Inhibins: from reproductive hormones to tumor suppressors. Trends Endocrinol Metab 21:174–180CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of AnatomyOtago School of Medical SciencesDunedinNew zealand