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Cryptotanshinone

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  • First Online:
Encyclopedia of Cancer

  • 196 Accesses

Synonyms

(R)-1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-phenanthro(1,2-b)furan-10,11-dione; 1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-(R)-phenanthro(1,2-b)furan-10,11-dione; 1,2,6,7,8,9-hexahydro-1,6,6-trimethyl[1,2-b]furan-10,11-dione; Cryptotanshinone; Tanshinone C

Definition

Cryptotanshinone is a cell-permeable diterpene quinone and natural product isolated from the root of Salvia miltiorrhiza Bunge (Fig. 1a), a widely used herb in China for treatment of cardiovascular and cerebrovascular diseases.

Fig. 1
figure 1

(a) Molecular structure of cryptotanshinone. (b) Salvia miltiorrhiza Bunge (http://bbs.zhong-yao.net/)

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References

  • Chen W, Luo Y, Liu L et al (2010) Cryptotanshinone inhibits cancer cell proliferation by suppressing mammalian target of rapamycin-mediated cyclin D1 expression and Rb phosphorylation. Cancer Prev Res (Phila) 3:1015–1025

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  • Luo Y, Chen W, Zhou H et al (2011) Cryptotanshinone inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3/ERK and small GTPase pathways. Cancer Prev Res (Phila) 4:2083–2091

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  • Park IJ, Kim MJ, Park OJ et al (2010) Cryptotanshinone sensitizes DU145 prostate cancer cells to Fas (APO1/CD95)-mediated apoptosis through Bcl-2 and MAPK regulation. Cancer Lett 298:88–98

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  • Shin DS, Kim HN, Shin KD et al (2009) Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res 69:193–202

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology and Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA, USA

    Shile Huang

  2. Department of Clinical Pharmacy, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China

    Wenxing Chen

Authors
  1. Shile Huang
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  2. Wenxing Chen
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Corresponding author

Correspondence to Shile Huang .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Huang, S., Chen, W. (2014). Cryptotanshinone. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_7124-8

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_7124-8

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

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