Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Cryptotanshinone

  • Shile Huang
  • Wenxing Chen
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7124-8

Synonyms

Definition

Cryptotanshinone is a cell-permeable diterpene quinone and natural product isolated from the root of Salvia miltiorrhiza Bunge (Fig. 1a), a widely used herb in China for treatment of cardiovascular and cerebrovascular diseases.

Keywords

Androgen Receptor Bovine Aortic Endothelial Cell DU145 Prostate Cancer Cell Prostate Cancer Cell Proliferation Inhibit Tube Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Chen W, Luo Y, Liu L et al (2010) Cryptotanshinone inhibits cancer cell proliferation by suppressing mammalian target of rapamycin-mediated cyclin D1 expression and Rb phosphorylation. Cancer Prev Res (Phila) 3:1015–1025CrossRefGoogle Scholar
  2. Luo Y, Chen W, Zhou H et al (2011) Cryptotanshinone inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3/ERK and small GTPase pathways. Cancer Prev Res (Phila) 4:2083–2091CrossRefGoogle Scholar
  3. Park IJ, Kim MJ, Park OJ et al (2010) Cryptotanshinone sensitizes DU145 prostate cancer cells to Fas (APO1/CD95)-mediated apoptosis through Bcl-2 and MAPK regulation. Cancer Lett 298:88–98CrossRefPubMedGoogle Scholar
  4. Shin DS, Kim HN, Shin KD et al (2009) Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res 69:193–202CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular Biology and Feist-Weiller Cancer CenterLouisiana State University Health Sciences CenterShreveportUSA
  2. 2.Department of Clinical Pharmacy, College of PharmacyNanjing University of Chinese MedicineNanjingChina