Definition
Nestin is a class VI intermediate filament (IF) protein physiologically expressed in stem/progenitor cells in the mammalian central nervous system (CNS) during development.
Characteristics
Nestin is a class VI IF protein that was originally described as a neuronal stem cell marker expressed during CNS development. Upon cellular differentiation, nestin is downregulated and replaced by neurofilament, a tissue-specific intermediate filament. Nestin is also expressed in nonneuronal immature or progenitor cells in some normal tissues. Under pathological conditions, nestin is re-expressed in:
Repair processes
Various neoplasms
Proliferating vascular endothelial cells
Structure
The nestin gene has four exons and three introns in human. Nestin is a large protein (>1,600 amino acids) containing a short N terminus and an unusually long C terminus. The C terminus interacts with other IFs including vimentin, desmin, or internexin, forming heterodimers and mixed polymers. The long...
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References
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Ishiwata, T. (2014). Nestin. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_7123-4
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DOI: https://doi.org/10.1007/978-3-642-27841-9_7123-4
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Publisher Name: Springer, Berlin, Heidelberg
Online ISBN: 978-3-642-27841-9
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