Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Toshiyuki Ishiwata
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7123-4


Nestin is a class VI intermediate filament (IF) protein physiologically expressed in stem/progenitor cells in the mammalian central nervous system (CNS) during development.


Nestin is a class VI IF protein that was originally described as a neuronal stem cell marker expressed during CNS development. Upon cellular differentiation, nestin is downregulated and replaced by neurofilament, a tissue-specific intermediate filament. Nestin is also expressed in nonneuronal immature or progenitor cells in some normal tissues. Under pathological conditions, nestin is re-expressed in:
  • Repair processes

  • Various neoplasms

  • Proliferating vascular endothelial cells


The nestin gene has four exons and three introns in human. Nestin is a large protein (>1,600 amino acids) containing a short N terminus and an unusually long C terminus. The C terminus interacts with other IFs including vimentin, desmin, or internexin, forming heterodimers and mixed polymers. The long...


Acute Pancreatitis Pancreatic Cancer Cell Inflammatory Breast Cancer Acinar Cell Carcinoma Granular Cell Tumor 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Integrated Diagnostic Pathology, Graduate School of MedicineNippon Medical SchoolTokyoJapan