Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Nestin

  • Toshiyuki Ishiwata
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7123-4

Definition

Nestin is a class VI intermediate filament (IF) protein physiologically expressed in stem/progenitor cells in the mammalian central nervous system (CNS) during development.

Characteristics

Nestin is a class VI IF protein that was originally described as a neuronal stem cell marker expressed during CNS development. Upon cellular differentiation, nestin is downregulated and replaced by neurofilament, a tissue-specific intermediate filament. Nestin is also expressed in nonneuronal immature or progenitor cells in some normal tissues. Under pathological conditions, nestin is re-expressed in:
  • Repair processes

  • Various neoplasms

  • Proliferating vascular endothelial cells

Structure

The nestin gene has four exons and three introns in human. Nestin is a large protein (>1,600 amino acids) containing a short N terminus and an unusually long C terminus. The C terminus interacts with other IFs including vimentin, desmin, or internexin, forming heterodimers and mixed polymers. The long...

Keywords

Acute Pancreatitis Pancreatic Cancer Cell Inflammatory Breast Cancer Acinar Cell Carcinoma Granular Cell Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Ishiwata T, Kudo M, Onda M, Fujii T, Teduka K, Suzuki T, Korc M, Naito Z (2006) Defined localization of nestin-expressing cells in L-arginine-induced acute pancreatitis. Pancreas 32(4):360–368. doi:10.1097/01.mpa.0000220860.01120.21, PMID: 16670618CrossRefPubMedGoogle Scholar
  2. Ishiwata T, Matsuda Y, Naito Z (2011) Nestin in gastrointestinal and other cancers: effects on cells and tumor angiogenesis. World J Gastroenterol 17(4):409–418, Review. [PMID: 21274370; PMCID: PMC3027007]PubMedCentralCrossRefPubMedGoogle Scholar
  3. Lendahl U, Zimmerman LB, McKay RD (1990) CNS stem cells express a new class of intermediate filament protein. Cell 60(4):585–595. doi:10.1016/0092-8674(90)90662-X, PMID: 1689217CrossRefPubMedGoogle Scholar
  4. Matsuda Y, Ishiwata T, Yoshimura H, Hagio M, Arai T (2015) Inhibition of nestin suppresses stem cell phenotype of glioblastomas through the alteration of post-translational modification of heat shock protein HSPA8/HSC71. Cancer Lett 28;357(2):602–11. doi: 10.1016/j.canlet.2014.12.030Google Scholar
  5. Matsuda Y, Kure S, Ishiwata T (2012) Nestin and other putative cancer stem cell markers in pancreatic cancer. Med Mol Morphol 45(2):59–65. doi:10.1007/s00795-012-0571-x. ReviewGoogle Scholar
  6. Matsuda Y, Naito Z, Kawahara K, Nakazawa N, Korc M, Ishiwata T (2011) Nestin is a novel target for suppressing pancreatic cancer cell migration, invasion and metastasis. Cancer Biol Ther 11(5):512–523, PMID: 21258211PubMedCentralCrossRefPubMedGoogle Scholar
  7. Matsuda Y, Yoshimura H, Ueda J, Naito Z, Korc M, Ishiwata T (2014) Nestin delineates pancreatic cancer stem cells in metastatic foci of NOD/Shi-scid IL2Rγ(null) (NOG) mice. Am J Pathol 184(3):674–85. doi: 10.1016/j.ajpath.2013.11.014Google Scholar
  8. Strojnik T, Rosland GV, Sakariassen PO, Kavalar R, Lah T (2007) Neural stem cell markers, nestin and musashi proteins, in the progression of human glioma: correlation of nestin with prognosis of patient survival. Surg Neurol 68(2):133–143. doi:10.1016/j.surneu.2006.10.050, discussion 143–134 [PMID: 17537489]CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Integrated Diagnostic Pathology, Graduate School of MedicineNippon Medical SchoolTokyoJapan