Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

LPA

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7121-6

Synonyms

Definition

Lysophosphatidic acid is a ubiquitous constituent of membranes, an intermediate biosynthetic precursor for the formation of similar molecules and also an extracellular signaling phospholipid mediator that can elicit signaling cascades through binding to a family of G protein-coupled receptors. The structure is composed of a phosphate polar head group, a glycerol backbone linker and a single hydrocarbon chain with varying numbers of carbons forming the hydrophobic, fatty acid tail.

Characteristics

Lysophosphatidic acid is found in circulating blood serum and plasma bound to albumin or gelsolin and is a normal component involved in the physiology of wound healing and platelet aggregation. It is also...

Keywords

Follicular Fluid Lysophosphatidic Acid Blister Fluid Human Hair Follicle Murine Melanoma Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Hama K, Aoki J (2010) LPA3, a unique G protein-coupled receptor for lysophosphatidic acid. Prog Lipid Res 49:335–342CrossRefPubMedGoogle Scholar
  2. Herr DR, Chun J (2007) Effects of LPA and S1P on the nervous system and implication for their involvement in disease. Curr Drug Targets 8:155–167CrossRefPubMedGoogle Scholar
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  5. Pasternack SM, von Kugelgen I, Aboud KA, Lee Y et al (2008) G protein-coupled receptor p2y5 and its ligand LPA are involved in maintenance of human hair growth. Nat Genet 40:329–334CrossRefPubMedGoogle Scholar
  6. Tigyi G, Parrill AL (2003) Molecular mechanisms of lysophosphatidic acid action. Prog Lipid Res 42:498–526CrossRefPubMedGoogle Scholar
  7. Tokumura A, Morishige J (2008) Potential role of lysophosphatidic acid on vascular inflammation and atherosclerosis. In: Tselepis AD (ed) Bioactive phospholipids: role in inflammation and atherosclerosis, vol 2. Transworld Research Network, Kerala, pp 1–20Google Scholar
  8. Ye X (2008) Lysophospholipid signaling in the function and pathology of the reproductive system. Hum Reprod Update 14(5):519–538CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Pharmaceutical and Biomedical Sciences, Georgia Cancer Coalition Distinguished Cancer ScholarUniversity of Georgia and College of PharmacyAthensUSA