Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Mandi Murph
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7121-6



Lysophosphatidic acid is a ubiquitous constituent of membranes, an intermediate biosynthetic precursor for the formation of similar molecules and also an extracellular signaling phospholipid mediator that can elicit signaling cascades through binding to a family of G protein-coupled receptors. The structure is composed of a phosphate polar head group, a glycerol backbone linker and a single hydrocarbon chain with varying numbers of carbons forming the hydrophobic, fatty acid tail.


Lysophosphatidic acid is found in circulating blood serum and plasma bound to albumin or gelsolin and is a normal component involved in the physiology of wound healing and platelet aggregation. It is also...


Follicular Fluid Lysophosphatidic Acid Blister Fluid Human Hair Follicle Murine Melanoma Cell Line 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Pharmaceutical and Biomedical Sciences, Georgia Cancer Coalition Distinguished Cancer ScholarUniversity of Georgia and College of PharmacyAthensUSA