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Choline kinase is the first enzyme in the Kennedy pathway of biosynthesis of phosphatidylcholine (PC), one of the major components of eukaryotic membranes (Fig. 1). This enzyme catalyzes the phosphorylation of choline (Cho) or ethanolamine (ETA) in the presence of ATP and magnesium as a cofactor to yield phosphocholine (PCho) or phosphoethanolamine (PEta), respectively (Fig. 2).
References
Aoyama C, Liao H, Ishidate K (2004) Structure and function of choline kinase isoforms in mammalian cells. Prog Lipid Res 43(3):266–281
Glunde K, Bhujwalla ZM, Ronen SM (2011) Choline metabolism in malignant transformation. Nat Rev Cancer 11(12):835–848
Lacal JC (2001) Choline kinase: a novel target for antitumor drugs. IDrugs 4(4):419–426
RamÃrez de Molina A, Sarmentero-Estrada J, Belda-Iniesta C et al (2007) Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study. Lancet Oncol 8(10):889–897
Wu G, Vance DE (2010) Choline kinase and its function. Biochem Cell Biol 88(4):559–564
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de Molina, A.R. (2014). Choline Kinase. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_7117-3
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DOI: https://doi.org/10.1007/978-3-642-27841-9_7117-3
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Publisher Name: Springer, Berlin, Heidelberg
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