Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Cucurbitacin B

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7113-6

Definition

Cucurbitacin B is a bitter oxygenated triterpene produced principally by plant species classified in the cucumber family (Cucurbitaceae).

Characteristics

Chemical names

(2S,4R,23E)-2,16Beta,20-trihydroxy-9beta,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-5,23-dien-25-yl acetate

1,2-Dihydro-alpha-elaterin

2Beta,16alpha,20,25-tetrahydroxy-9-methyl-19-nor-9beta,10alpha-lanosta-5,23-diene-3,11,22-trione,25-acetate

2Beta,16alpha,20,25-tetrahydroxy-9-methyl-3,11,22-trioxo-19-nor-9beta,10alpha-lanosta-5,23-dien-25-yl acetate

Activities on Cancer Cells

Cucurbitacin B has the ability to kill multiple types of cancer cell lines at very low concentration in vitro. Cucurbitacin B from Helicteres isora L. (family Sterculiaceae) abrogated the survival of nasopharyngeal carcinoma (KB) cells with an IC50 value at a concentration below 10−5 μg/mL. Cucurbitacin B isolated from Begonia tuberhybrida Voss var. alba (family Begoniaceae) and Bryonia albaL. (family Cucurbitaceae)...

Keywords

Pancreatic Cancer Pancreatic Cancer Cell Human Breast Adenocarcinoma Human Nasopharyngeal Carcinoma Human Ductal Breast 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Hoennissen NH, Iwanski GB, Doan NB, Okamoto R, Lin P, Abbassi S, Jee HS, Yin D, Toh M, Xie WD, Said JW, Koeffler HP (2009) Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells. Cancer Res 69(14):5876–5884CrossRefGoogle Scholar
  2. Iwanski GB, Lee DH, En-Gal S, Doan NB, Castor B, Vogt M, Toh M, Bokemeyer C, Said JW, Thoennissen NH, Koeffler HP (2010) Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer. Br J Pharmacol 160(4):998–1007PubMedCentralPubMedCrossRefGoogle Scholar
  3. Jian CC, Ming HC, Rui LN, Cordel GA, Qiuz SX (2005) Cucurbitacins and cucurbitane glycosides: structures and biological activities. Nat Prod Rep 22(3):386–399CrossRefGoogle Scholar
  4. Sun C, Zhang M, Shan X, Zhou X, Yang J, Wang Y, Li–Ling J, Deng Y (2010) Inhibitory effect of cucurbitacin e on pancreatic cancer cells growth via STAT3 signaling. J Cancer Res Clin Oncol 136(4):603–610PubMedCrossRefGoogle Scholar
  5. Zhang M, Sun C, Shan X, Yang X, Li–Ling J, Deng Y (2010) Inhibition of pancreatic cancer cell growth by cucurbitacin b through modulation of signal transducer and activator of transcription 3 signaling. Pancreas 39(6):923–992PubMedCrossRefGoogle Scholar

Copyright information

© © Crown Copyright 2012

Authors and Affiliations

  1. 1.University of NottinghamNottinghamUK