Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Cucurbitacin B

  • Christophe Wiart
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7113-6


Cucurbitacin B is a bitter oxygenated triterpene produced principally by plant species classified in the cucumber family (Cucurbitaceae).


Chemical names

(2S,4R,23E)-2,16Beta,20-trihydroxy-9beta,10,14-trimethyl-1,11,22-trioxo-4,9-cyclo-9,10-secocholesta-5,23-dien-25-yl acetate



2Beta,16alpha,20,25-tetrahydroxy-9-methyl-3,11,22-trioxo-19-nor-9beta,10alpha-lanosta-5,23-dien-25-yl acetate

Activities on Cancer Cells

Cucurbitacin B has the ability to kill multiple types of cancer cell lines at very low concentration in vitro. Cucurbitacin B from Helicteres isora L. (family Sterculiaceae) abrogated the survival of nasopharyngeal carcinoma (KB) cells with an IC50 value at a concentration below 10−5 μg/mL. Cucurbitacin B isolated from Begonia tuberhybrida Voss var. alba (family Begoniaceae) and Bryonia albaL. (family Cucurbitaceae)...


Pancreatic Cancer Pancreatic Cancer Cell Human Breast Adenocarcinoma Human Nasopharyngeal Carcinoma Human Ductal Breast 
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Copyright information

© © Crown Copyright 2012

Authors and Affiliations

  1. 1.University of NottinghamNottinghamUK