Definition
SIRT1 (sirtuin 1), a mammalian counterpart of the yeast silent information regulator 2 (Sir2), is a proto-member of the sirtuin family. SIRT1 is an NAD-dependent protein deacetylase. SIRT1 is crucial for cell survival, metabolism, senescence, and stress response in several cell types and tissues.
Characteristics
SIRT1 is an NAD+-dependent protein deacetylase within the mammalian sirtuin family. The enzyme is conserved from yeast to human and is the first known mammalian sirtuin. SIRT1 is an important regulator of physiology, calorie restriction, aging, and cancer (Haigis and Guarente 2006; Haigis and Sinclair 2010). It is localized in both the nucleus and the cytoplasm. SIRT1 is crucial for cell survival, metabolism, senescence, and stress response in several cell types and tissues. Both histone and nonhistone targets of SIRT1 have been identified.
SIRT1 has...
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References
Brooks CL, Gu W (2009) How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer 9:123–128
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Haigis MC, Guarente LP (2006) Mammalian sirtuins – emerging roles in physiology, aging, and calorie restriction. Genes Dev 20:2913–2921
Haigis MC, Sinclair DA (2010) Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol 5:253–295
Herranz D, Serrano M (2010) SIRT1: recent lessons from mouse models. Nat Rev Cancer 10:819–823
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© 2014 Springer-Verlag Berlin Heidelberg
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He, YY. (2014). SIRT1. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_7112-4
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DOI: https://doi.org/10.1007/978-3-642-27841-9_7112-4
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Publisher Name: Springer, Berlin, Heidelberg
Online ISBN: 978-3-642-27841-9
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