Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

SIRT1

  • Yu-Ying He
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7112-4

Synonyms

Definition

SIRT1 (sirtuin 1), a mammalian counterpart of the yeast silent information regulator 2 (Sir2), is a proto-member of the sirtuin family. SIRT1 is an NAD-dependent protein deacetylase. SIRT1 is crucial for cell survival, metabolism, senescence, and stress response in several cell types and tissues.

Characteristics

SIRT1 is an NAD+-dependent protein deacetylase within the mammalian sirtuin family. The enzyme is conserved from yeast to human and is the first known mammalian sirtuin. SIRT1 is an important regulator of physiology, calorie restriction, aging, and cancer (Haigis and Guarente 2006; Haigis and Sinclair 2010). It is localized in both the nucleus and the cytoplasm. SIRT1 is crucial for cell survival, metabolism, senescence, and stress response in several cell types and tissues. Both histone and nonhistone targets of SIRT1 have been identified.

SIRT1 has...

Keywords

Nucleotide Excision Repair Promote Cell Survival Xeroderma Pigmentosum SIRT1 Expression SIRT1 Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Brooks CL, Gu W (2009) How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer 9:123–128PubMedCentralCrossRefPubMedGoogle Scholar
  2. Finkel T, Deng CX, Mostoslavsky R (2009) Recent progress in the biology and physiology of sirtuins. Nature 460:587–591PubMedCentralCrossRefPubMedGoogle Scholar
  3. Haigis MC, Guarente LP (2006) Mammalian sirtuins – emerging roles in physiology, aging, and calorie restriction. Genes Dev 20:2913–2921CrossRefPubMedGoogle Scholar
  4. Haigis MC, Sinclair DA (2010) Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol 5:253–295PubMedCentralCrossRefPubMedGoogle Scholar
  5. Herranz D, Serrano M (2010) SIRT1: recent lessons from mouse models. Nat Rev Cancer 10:819–823PubMedCentralCrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Medicine/DermatologyUniversity of ChicagoChicagoUSA