Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Adoptive T Cell Transfer

  • Mingjun Wang
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7111-1

Synonyms

Definition

Adoptive T cell transfer is an approach to treat various types of diseases, particularly malignant tumors by intravenous injection of autologous T cells modified with or without a gene encoding a specific antigen receptor. T cells are usually isolated from the tumor tissues or peripheral blood mononuclear cells (PBMCs) of cancer patients, stimulated with tumor antigens or modified with a gene encoding a specific antigen receptor, then expanded in vitro to a large quantity before infusion back into the patient for treatment.

Characteristics

Adoptive T cell transfer is an approach of cancer immunotherapy, which has emerged as a novel and promising approach for treatment of cancer patients with advanced or refractory diseases, since traditional cancer treatments, including surgery, chemotherapy, and radiation therapy, have demonstrated very limited efficacy for patients with late-stage diseases. In...

Keywords

Acute Lymphocytic Leukemia Chronic Lymphocytic Leukemia Cell Transfer Chimeric Antigen Receptor Cancer Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Cheadle EJ, Gornall H, Baldan V, Hanson V, Hawkins RE, Gilham DE (2014) CAR T cells: driving the road from the laboratory to the clinic. Immunol Rev 257(1):91–106CrossRefPubMedGoogle Scholar
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  3. Restifo NP, Dudley ME, Rosenberg SA (2012) Adoptive immunotherapy for cancer: harnessing the T cell response. Nat Rev Immunol 12(4):269–281CrossRefPubMedGoogle Scholar
  4. Ruella M, Kalos M (2014) Adoptive immunotherapy for cancer. Immunol Rev 257(1):14–38CrossRefPubMedGoogle Scholar
  5. Yee C (2014) The use of endogenous T cells for adoptive transfer. Immunol Rev 257(1):250–263CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Center for Inflammation and EpigeneticsHouston Methodist Research InstituteHoustonUSA