Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Peptidylarginine Deiminase Enzymes

  • Sunish Mohanan
  • Scott Coonrod
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7106-5



The PADs are a family of posttranslational modification enzymes that convert positively charged protein-bound arginine and methylarginine residues to neutrally charged, non-ribosomally encoded citrulline residues. This process is referred to as citrullination or alternatively as deimination.



Citrullination of arginine and methylarginine residues by PAD enzymes affects the tertiary structure of target substrates and alters protein-protein interactions, impacting various cellular processes (Fig. 1). Protein citrullination has recently gained increased attention due to its proven role in the pathogenesis of various inflammatory conditions such as rheumatoid arthritis, multiple sclerosis, psoriasis, and COPD and emerging roles in various carcinomas in humans and animals. In this essay, we will discuss the tissue specificity of the five PAD isoforms and the potential role of this enzyme family in...


Estrous Cycle Neutrophil Extracellular Trap Neutrophil Extracellular Trap Formation Canine Mammary Gland Protein Arginine Deiminases 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Baker Institute for Animal Health, Department of Biomedical Sciences, School of Veterinary MedicineCornell UniversityIthacaUSA