Living reference work entry
Estrogen signaling refers to the transduction pathways which mediate the multifaceted biological actions of estrogens. Estrogen signaling triggers both rapid and genomic responses mainly through: (1) the nuclear estrogen receptor (ER)α and ERβ which act as transcription factors, (2) the membrane-localized ERs, and (3) the G protein-coupled estrogen receptor (GPER), formerly named GPR30 (Fig. 1).
KeywordsEstrogen Signaling Inositol Trisphosphate Membrane Estrogen Receptor EGFR Transactivation PI3K Signaling Cascade
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- De Marco P, Cirillo F, Vivacqua A, Malaguarnera R, Belfiore A, Maggiolini M (2015) Novel Aspects Concerning the Functional Cross-Talk between the Insulin/IGF-I System and Estrogen Signaling in Cancer Cells. Front Endocrinol (Lausanne) 6:30Google Scholar
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