Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Estrogen Signaling

  • Rosamaria Lappano
  • Marcello MaggioliniEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7104-3


Estrogen signaling refers to the transduction pathways which mediate the multifaceted biological actions of estrogens. Estrogen signaling triggers both rapid and genomic responses mainly through: (1) the nuclear estrogen receptor (ER)α and ERβ which act as transcription factors, (2) the membrane-localized ERs, and (3) the G protein-coupled estrogen receptor (GPER), formerly named GPR30 (Fig. 1).


Estrogen Signaling Inositol Trisphosphate Membrane Estrogen Receptor EGFR Transactivation PI3K Signaling Cascade 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Pharmacy and Health and Nutritional SciencesUniversity of Calabria87036 RendeItaly