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CDCP1

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

  • 128 Accesses

Synonyms

CD318 (cluster of differentiation 318); CDCP1 (CUB domain-containing protein 1); gp140 (glycoprotein 140); SIMA135 (subtractive immunization M(+)HEp3 associated 135 kDa protein); Trask (transmembrane and associated with Src kinases)

Definition

CDCP1 is an 836-amino-acid protein that is present in cells as an apparent 140 kDa full-length protein and an 80 kDa fragment. It is overexpressed in some cancers and has been implicated in invasion, metastasis, and tumor progression.

Characteristics

Discovery

The CDCP1 gene was first discovered in 2001 when high levels of mRNA were found in colon cancer cells, and the protein was later identified in three separate instances. SIMA135 was described as an N-glycosylated and tyrosine phosphorylated membrane protein upregulated in metastatic human epidermoid carcinoma cells in 2003. It was later identified as glycoprotein 140, a protein that was highly phosphorylated when cells were cultured in suspension and could be cleaved to an 80 kDa...

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References

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See Also

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Author information

Authors and Affiliations

  1. Department of Pharmacology and Therapeutics and the UF and Shands Cancer Center, University of Florida, Gainesville, FL, USA

    Brian Law & Stephan C. Jahn

Authors
  1. Brian Law
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  2. Stephan C. Jahn
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Corresponding author

Correspondence to Brian Law .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Law, B., Jahn, S.C. (2014). CDCP1. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_7103-10

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_7103-10

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

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