Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Noncoding RNA

  • Kotb Abdelmohsen
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7101-4



Noncoding RNAs are RNA molecules that do not encode proteins. They constitute the vast majority of human genome, ~97 % (Fig. 1). Recent research revealed functional roles for several noncoding RNAs, but it is not known if all are functional.


Chronic Lymphocytic Leukemia microRNA Expression HOTAIR Expression Piwi Protein Silence Gene Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.


  1. Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116(2):281–297CrossRefPubMedGoogle Scholar
  2. Esteller M (2011) Non-coding RNAs in human disease. Nat Rev Genet 12(12):861–874. doi:10.1038/nrg3074, PMID: 22094949CrossRefPubMedGoogle Scholar
  3. Kowalczyk MS, Higgs DR, Gingeras TR (2012) Molecular biology: RNA discrimination. Nature 482(7385):310–311. doi:10.1038/482310aCrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg (outside the USA) 2012

Authors and Affiliations

  1. 1.RNA Regulation Section, National Institute on Aging, National Institutes of HealthBiomedical Research CenterBaltimoreUSA