Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

NY-ESO-1

  • Mingjun Wang
  • Guru Sonpavde
  • Helen Y. Wang
  • Rong-Fu Wang
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7100-8

Synonyms

Definition

NY-ESO-1 is a tumor-specific antigen of the cancer/testis antigen family and is encoded by a gene located at Xq28. It is composed of 180 amino acids with a molecular weight of 18 kD. NY-ESO-1 is strongly expressed in various types of cancers, but not in normal somatic tissues or cells except normal testes, ovary, and placenta.

Characteristics

NY-ESO-1 was first identified as a tumor antigen in 1997 by Chen et al. (1997a) using sera from a patient with esophageal squamous cell carcinoma after serological analysis of recombinant cDNA expression libraries (SEREX). Shortly afterwards, Jäger et al. (1998) and Wang et al. (1998a) independently reported that NY-ESO-1 could be recognized by T cells from melanoma patients. Thus, NY-ESO-1 can induce both antibody and T-cell responses in the...

Keywords

Esophageal Squamous Cell Carcinoma Synovial Cell Sarcoma Strong Immunogenicity Antigen Family Beneficial Clinical Outcome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Notes

Acknowledgements

We would like to thank Drs. Adebusola Alagbala Ajibade and Christopher Loo for manuscript editing.

References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Mingjun Wang
    • 1
  • Guru Sonpavde
    • 2
  • Helen Y. Wang
    • 1
  • Rong-Fu Wang
    • 1
  1. 1.Center for Inflammation and EpigeneticsHouston Methodist Research InstituteHoustonUSA
  2. 2.Texas Oncology and Veterans Affairs Medical Center and the Baylor College of MedicineHoustonUSA