Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Oxygen Sensing

  • Zhong Yun
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7094-7

Synonyms

Definition

Oxygen sensing refers to the ability of cells to detect and respond to changes of intracellular oxygen concentrations. Because cells often experience decreased oxygenation under both physiological and pathological conditions, oxygen sensing is also referred to as hypoxia sensing. This entry focuses on the common mechanisms of oxygen sensing in mammalian cells.

Characteristics

Molecular oxygen (dioxygen O2) is a vital element for the majority of life forms on earth. The atmospheric O2concentration is approximately 20.9 % at the sea level. Under physiological conditions, oxygen concentrations are maintained approximately in the range of 2–10 % depending on the tissue types in mammals. However, mammalian cells can be exposed to high levels (up to 20.9 %) of oxygen concentrations due to physical wounding. On the other hand, oxygen concentrations in mammalian cells can decrease to 0–1 % due to certain diseases including ischemia, cardiovascular...

Keywords

Histone Demethylases AlkB Gene Remove Methyl Group Methylated Lysine Residue Intracellular Oxygen Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

References

  1. Aragonés J, Fraisl P, Baes M, Carmeliet P (2009) Oxygen sensors at the crossroad of metabolism. Cell Metab 9(1):11–22CrossRefPubMedGoogle Scholar
  2. Loenarz C, Schofield CJ (2011) Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases. Trends Biochem Sci 36(1):7–18CrossRefPubMedGoogle Scholar
  3. Semenza GL (2011) Oxygen sensing, homeostasis, and disease. N Engl J Med 365:537–547CrossRefPubMedGoogle Scholar
  4. Vanderkooi JM, Erecinska M, Silve IA (1991) Oxygen in mammalian tissue: methods of measurement and affinities of various reactions. Am J Physiol 260(6 Pt1):C1131–C1150PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Therapeutic RadiologyYale School of MedicineNew HavenUSA