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Encyclopedia of Cancer pp 1–4Cite as

p27

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Synonyms

CDKN4; Cyclin-dependent kinase inhibitor 1B (CDKI1B); KIP1; MEN1B; MEN4; p27KIP1

Definition

p27 is a 198-amino acid protein encoded by the cyclin-dependent kinase inhibitor 1B (CDKN1B) gene on the short arm of chromosome 12 and is a member of the CIP/KIP family of cyclin-dependent kinase (CDK) inhibitor proteins (p21, p27, and p57). Through its binding to cyclin E/CDK2 complexes, p27 acts as a cell cycle inhibitor at G1 phase. When quiescent cells begin to divide and enter cell division, p27 is phosphorylated by CDKs and rapidly degraded by ubiquitination. p27 has been examined as a tumor suppressor, because its decreased expression is often associated with poor survival in cancer patients. Recently, it has also been found that p27 is expressed in the cytoplasm of some sets of cancer cells and promotes tumor aggressiveness.

Characteristics

The cell cycle is mainly controlled by several proteins termed cyclins and cyclin-dependent kinases (CDKs), which are activated in a strict...

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References

  • Chu IM, Hengst L, Slingerland JM (2008) The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Nat Rev Cancer 8:253–267

    Article  CAS  PubMed  Google Scholar 

  • Susaki E, Nakayama KI (2009) Functional similarities and uniqueness of p27 and p57: insight from a knock-in mouse model. Cell Cycle 8:2497–2501

    Article  CAS  PubMed  Google Scholar 

  • Wander SA, Zhao D, Slingerland JM (2011) p27: a barometer of signaling deregulation and potential predictor of response to targeted therapies. Clin Cancer Res 17:12–18

    Article  PubMed Central  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Medical Technology, Niigata University Graduate of Health Sciences, Niigata, Japan

    Yasunobu Matsuda

Authors
  1. Yasunobu Matsuda
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Corresponding author

Correspondence to Yasunobu Matsuda .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2014 Springer-Verlag Berlin Heidelberg

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Matsuda, Y. (2014). p27. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_7090-6

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_7090-6

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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