Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Wook-Jin Chae
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7089-6



Interleukin-17(IL-17, IL-17A) is the founding member of a group of the IL-17 cytokine family. In 1993, it was originally identified as a transcript from a rodent T cell hybridoma by Rouvier et al. and known as CTLA8 in rodents. IL-17 shows high homology to an open reading frame of the T lymphotropic rhadinovirus Herpesvirus saimiri. After the identification of IL-17 and of its crucial features, it has been extensively demonstrated that a number of both spontaneous and induced diseases were associated with IL-17 expression and production in humans and mice.


So far, the importance of IL-17 in human diseases and animal models were demonstrated in psoriasis, rheumatoid arthritis, Crohn’s disease, multiple sclerosis, hyper-immunoglobulin E syndrome, asthma, bacterial/fungal infection, as well as cancer. IL-17 is a delayed-type cytokine that acts as a potent mediator to increase recruit monocytes and neutrophils to the site of...


Th17 Cell Differentiation Human Cervical Cancer Cell Human Cervical Cancer Cell Line Syngeneic Immunocompetent Mouse Hematopoietic Tumor Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of ImmunobiologyYale University School of MedicineNew HavenUSA