Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Esophageal Adenocarcinoma

  • Landon IngeEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7087-1



Esophageal adenocarcinoma (EAC) is an epithelial malignancy of the lining of the esophagus. EAC is distinct from squamous cell carcinoma of the esophagus, arising from the glandular, metaplastic columnar epithelium characteristic of Barrett’s esophagus (BE).


Esophageal cancer is the sixth most frequent malignancy worldwide. Squamous cell carcinoma accounts for the majority of esophageal cancers; however, recent epidemiological data reveal increased incidence of EAC within Western countries. In particular, EAC now accounts for the majority of esophageal cancers in the USA and is one of the few malignancies whose incidence is continuing to increase in the USA (Simard et al. 2012). Five-year relative survival rates (2000–2007) are 47.8 % for localized cancer, 8.9 % for cancer with regional metastasis, and 2.9 % for cancer with distant metastasis. Overall survival for EAC is poor, a consequence of the...


Esophageal Cancer Esophageal Adenocarcinoma Mutational Inactivation Symptomatic Gastroesophageal Reflux Disease Metaplastic Columnar Epithelium 
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  1. Dulak AM et al (2013) Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. Nat Genet 45:478CrossRefPubMedGoogle Scholar
  2. Nones K et al (2014) Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis. Nat Commun 5:5224PubMedCentralCrossRefPubMedGoogle Scholar
  3. Quante M et al (2012) Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia. Cancer Cell 21:36PubMedCentralCrossRefPubMedGoogle Scholar
  4. Simard EP, Ward EM, Siegel R, Jemal A (2012) Cancers with increasing incidence trends in the United States: 1999 through 2008. CA: Cancer J ClinGoogle Scholar
  5. Weaver JM et al (2014) Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis. Nat Genet 46:837PubMedCentralCrossRefPubMedGoogle Scholar

See Also

  1. Barrett esophagus (2012) In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 342. doi:10.1007/978-3-642-16483-5_527Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Norton Thoracic InstituteSt. Joseph’s Hospital and Medical CenterPhoenixUSA