Esophageal adenocarcinoma (EAC) is an epithelial malignancy of the lining of the esophagus. EAC is distinct from squamous cell carcinoma of the esophagus, arising from the glandular, metaplastic columnar epithelium characteristic of Barrett’s esophagus (BE).
Esophageal cancer is the sixth most frequent malignancy worldwide. Squamous cell carcinoma accounts for the majority of esophageal cancers; however, recent epidemiological data reveal increased incidence of EAC within Western countries. In particular, EAC now accounts for the majority of esophageal cancers in the USA and is one of the few malignancies whose incidence is continuing to increase in the USA (Simard et al. 2012). Five-year relative survival rates (2000–2007) are 47.8 % for localized cancer, 8.9 % for cancer with regional metastasis, and 2.9 % for cancer with distant metastasis. Overall survival for EAC is poor, a consequence of the...
KeywordsEsophageal Cancer Esophageal Adenocarcinoma Mutational Inactivation Symptomatic Gastroesophageal Reflux Disease Metaplastic Columnar Epithelium
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