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Palladium-Based Anti-Cancer Therapeutics

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

Synonyms

Palladium antitumor agents; Palladium antitumor compounds; Palladium drugs; Palladium-based drugs

Definition

Palladium-based anticancer drugs are a range of compounds containing the platinum group metal (PGM), palladium, in one of its various forms including metallic palladium (Pd(0)) and palladium ions in either the 2+ or 4+ oxidation states. In addition, radioactive 103Pd has also been used in cancer therapeutics. Examples include its use in fluoroscopy, a medical imaging technique which involves the real-time observation of internal organs, and in brachytherapy which uses medical implants of radioactive palladium-103 seeds.

Characteristics

In this section, the advantages and disadvantages of palladium-based drugs over other metal-based drugs will be considered, specifically focusing on the inherent chemical and physical properties of palladium and how these influence drug–DNA interactions.

Palladium

Palladium is a platinum group metal and as such is very similar to platinum...

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References

  • Abu-Surrah AS, Kettunen M (2006) Platinum Group Antitumor Chemistry: Design and development of New Anticancer Drugs Complementary to Cisplatin. Curr Med Chem 13:1337–1357

    Article  CAS  PubMed  Google Scholar 

  • Abu-Surrah AS, Al-Sa’doni HH, Abdalla MY (2008) Palladium-based chemotherapeutic agents: Routes toward complexes with good antitumor activity. Cancer Ther 6:1–10

    CAS  Google Scholar 

  • Aliwaini S, Swarts AJ, Blanckenberg A, Mapolie SF, Prince S (2013) A novel binuclear palladacycle complex inhibits melanoma growth in vitro and in vivo through apoptosis and autophagy. Biochem Pharm 86:1650–1663

    Article  CAS  PubMed  Google Scholar 

  • Aliwaini S, Peres J, Kröger WL, Blanckenberg A, de la Mare J, Edkins AL, Mapolie SF, Prince S (2014) The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells. Cancer Lett 357:206–218

    Article  PubMed  Google Scholar 

  • Blasko JC, Grimm PD, Sylvster JE, Badiozamani KR, Hoak D, Cavanagh W (2000) Palladium-103 brachytherapy for prostate carcinoma. Int J Radiat Oncol Biol Phys 46:839–850

    Article  CAS  PubMed  Google Scholar 

  • Caires ACF (2007) Recent Advances Involving Palladium (II) Complexes for the Cancer Therapy. Anticancer Agents Med Chem 7:484–491

    Article  CAS  PubMed  Google Scholar 

  • Gao E, Sun Y, Liu Q, Duan L (2006) An anticancer metallobenzylmalonate: crystal structure and anticancer activity of a palladium complex of 2,2'-bipyridine and benzylmalonate. J Coord Chem 59:1295–1300

    Article  CAS  Google Scholar 

  • Gao E-J, Wang K-H, Gu X-F, Yu Y, Sun Y-G, Zhang W-Z, Yin H-X, Wu Q, Zhu M-C, Yan X-M (2007) A novel binuclear palladium complex with benzothiazole-2-thiolate: Synthesis, crystal structure and interaction with DNA. J Inorg Biochem 101:1404–1409

    Article  CAS  PubMed  Google Scholar 

  • Gao E, Liu C, Zhu M, Lin H, Wu Q, Liu L (2009) Current Development of Pd (II) Complexes as Potential Antitumor Agents. Anticancer Agents Med Chem 9:356–368

    Article  CAS  PubMed  Google Scholar 

  • Kapdi AR, Fairlamb IJS (2014) Anti-cancer palladium complexes: a focus on PdX2L2, palladacycles and related complexes. Chem Soc Rev 43:4751–4777

    Article  CAS  PubMed  Google Scholar 

  • Mazor O, Brandis A, Plaks V, Neumark E, Rosenbach-Belkin V, Salomon Y, Scherz A (2005) WST11, A Novel Water-soluble Bacteriochlorophyll Derivative; Cellular Uptake, Pharmacokinetics, Biodistribution and Vascular-targeted Photodynamic Activity Using Melanoma Tumors as a Model. J Photochem Photobiol 81:342–351

    Article  CAS  Google Scholar 

  • Ramachandran L, Krishan CV, Nair CKK (2010) Radioprotection by α-Lipoic Acid Palladium Complex Formulation (POLY-MVA) in Mice. Cancer Biother Radiopharm 25:395–399

    Article  CAS  PubMed  Google Scholar 

  • Trachtenberg J, Bogaards A, Weersink RA, Haider MA, Evans A, McCluskey SA, Scherz A, Gertner MR, Yue C, Appu S, Aprikian A, Savard J, Wilson BC, Elhilali M (2007) Vascular Targeted Photodynamic Therapy With Palladium-Bacteriopheophorbide Photosensitizer for Recurrent Prostate Cancer Following Definitive Radiation Therapy: Assessment of Safety and Treatment Response. J Urol 178:1974–1979

    Article  CAS  PubMed  Google Scholar 

See Also

  • (2012) AKT. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 115. doi:10.1007/978-3-642-16483-5_163

    Google Scholar 

  • (2012) Antioxidant. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 216. doi:10.1007/978-3-642-16483-5_328

    Google Scholar 

  • (2012) Cancer stem cells. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 626. doi:10.1007/978-3-642-16483-5_815

    Google Scholar 

  • (2012) Caspase. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 674–675. doi:10.1007/978-3-642-16483-5_873

    Google Scholar 

  • (2012) Cell cycle. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 737. doi:10.1007/978-3-642-16483-5_994

    Google Scholar 

  • (2012) Cell death. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 737. doi:10.1007/978-3-642-16483-5_6724

    Google Scholar 

  • (2012) Cell lines. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 738. doi:10.1007/978-3-642-16483-5_1002

    Google Scholar 

  • (2012) Clearance. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 880. doi:10.1007/978-3-642-16483-5_1211

    Google Scholar 

  • (2012) Clinical trial. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 883–884. doi:10.1007/978-3-642-16483-5_1216

    Google Scholar 

  • (2012) Combination chemotherapy. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 952. doi:10.1007/978-3-642-16483-5_6902

    Google Scholar 

  • (2012) Cytotoxic. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1058. doi:10.1007/978-3-642-16483-5_1499

    Google Scholar 

  • (2012) DNA. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1129. doi:10.1007/978-3-642-16483-5_1663

    Google Scholar 

  • (2012) DNA replication. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1141. doi:10.1007/978-3-642-16483-5_1690

    Google Scholar 

  • (2012) Dose rate. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1155. doi:10.1007/978-3-642-16483-5_1715

    Google Scholar 

  • (2012) Fluoroscopy. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 1426–1427. doi:10.1007/978-3-642-16483-5_2215

    Google Scholar 

  • (2012) Half-life. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1625. doi:10.1007/978-3-642-16483-5_2554

    Google Scholar 

  • (2012) Isotope. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1921. doi:10.1007/978-3-642-16483-5_3164

    Google Scholar 

  • (2012) Lipophilicity. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2058. doi:10.1007/978-3-642-16483-5_3384

    Google Scholar 

  • (2012) Mitogen-activated protein kinase. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2336. doi:10.1007/978-3-642-16483-5_3770

    Google Scholar 

  • (2012) Oligonucleotide. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2606. doi:10.1007/978-3-642-16483-5_4207

    Google Scholar 

  • (2012) Phase I and II clinical trials. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2852. doi:10.1007/978-3-642-16483-5_4504

    Google Scholar 

  • (2012) Phospholipid bilayer. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2869. doi:10.1007/978-3-642-16483-5_4541

    Google Scholar 

  • (2012) Photosensitizer. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2881–2882. doi:10.1007/978-3-642-16483-5_4559

    Google Scholar 

  • (2012) Prostate cancer. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 3009–3010. doi:10.1007/978-3-642-16483-5_6576

    Google Scholar 

  • (2012) Radiation therapy. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3144. doi:10.1007/978-3-642-16483-5_4907

    Google Scholar 

  • (2012) Salvage chemotherapy. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3334. doi:10.1007/978-3-642-16483-5_6947

    Google Scholar 

  • (2012) STAT. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3502. doi:10.1007/978-3-642-16483-5_5481

    Google Scholar 

  • (2012) Therapeutic efficacy. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3667. doi:10.1007/978-3-642-16483-5_5764

    Google Scholar 

  • (2012) Thrombosis. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3678. doi:10.1007/978-3-642-16483-5_5795

    Google Scholar 

  • (2012) Toxicity. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3731. doi:10.1007/978-3-642-16483-5_5868

    Google Scholar 

  • (2012) Transcription. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3752. doi:10.1007/978-3-642-16483-5_5899

    Google Scholar 

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Authors and Affiliations

  1. Department of Human Biology, Health Science Faculty, Division of Cell Biology, University of Cape Town, Private Bag X1, 7700, Rondebosch, South Africa

    Sharon Prince

  2. Department of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, 7602, Matieland, South Africa

    Selwyn Mapolie & Angelique Blanckenberg

Authors
  1. Sharon Prince
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  2. Selwyn Mapolie
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  3. Angelique Blanckenberg
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Corresponding author

Correspondence to Sharon Prince .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Prince, S., Mapolie, S., Blanckenberg, A. (2015). Palladium-Based Anti-Cancer Therapeutics. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_7085-1

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_7085-1

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  • Online ISBN: 978-3-642-27841-9

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