Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Chorioallantoic Membrane

  • Domenico Ribatti
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7081-6



The chorioallantoic membrane – synonym chorioallantois – (abbreviated CAM) is a vascular membrane in eggs of some amniotes, such as birds and reptiles. The chick embryo chorioallantoic membrane is an extraembryonic adnexa that mediates gas exchanges between the avian embryo and the outer environment. Due to its extensive vascularization and easy accessibility, the CAM has been used as an experimental in vivo model to study angiogenesis and antiangiogenesis. Moreover, because of the lack of a fully developed immunocompetent system, the CAM represents a host tissue for tumor engrafting suitable to study various aspects of tumor angiogenesis and metastatic potential.



The classical assays for studying angiogenesis in vivo include the hamster cheek pouch, rabbit ear chamber, the dorsal skin and air sac, the chick embryo chorioallantoic membrane (CAM), and the iris and the avascular corneal of rodent eye. The allantois is...


Chick Embryo Gelatin Sponge Hamster Cheek Pouch Chicken Tissue Host Vessel 
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  1. Cimpean AM, Raica M, Ribatti D (2008) The chick embryo chorioallantoic membrane as a model to study tumor metastasis. Angiogenesis 11:311–319CrossRefPubMedGoogle Scholar
  2. Ribatti D (2008) Chick embryo chorioallantoic membrane as a useful tool to study angiogenesis. Int Rev Cell Mol Biol 270:181–224CrossRefPubMedGoogle Scholar
  3. Ribatti D (2010) The chick embryo chorioallantoic membrane in the study of angiogenesis and metastasis. Springer Science, Dordrecht, pp 1–124CrossRefGoogle Scholar
  4. Ribatti D (2014) The chick embryo chorioallantoic membrane as a model for tumor biology. Exp Cell Res 328:314–324CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Basic Medical Sciences, Neurosciences and Sensory OrgansUniversity of Bari Medical SchoolBariItaly