The chorioallantoic membrane – synonym chorioallantois – (abbreviated CAM) is a vascular membrane in eggs of some amniotes, such as birds and reptiles. The chick embryo chorioallantoic membrane is an extraembryonic adnexa that mediates gas exchanges between the avian embryo and the outer environment. Due to its extensive vascularization and easy accessibility, the CAM has been used as an experimental in vivo model to study angiogenesis and antiangiogenesis. Moreover, because of the lack of a fully developed immunocompetent system, the CAM represents a host tissue for tumor engrafting suitable to study various aspects of tumor angiogenesis and metastatic potential.
The classical assays for studying angiogenesis in vivo include the hamster cheek pouch, rabbit ear chamber, the dorsal skin and air sac, the chick embryo chorioallantoic membrane (CAM), and the iris and the avascular corneal of rodent eye. The allantois is...