Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Drug Discovery

  • Min-Jean Yin
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7080-4

Definition

In the field of cancer biology and oncologic pharmacology, drug discovery is the process by which cancer drugs are discovered and developed. The process of drug discovery involves identification of cancer targets, chemical or biological design and synthesis of molecules against a given target, and screening and characterization of these molecules for maximal therapeutic efficacy and minimal toxicity. Once a molecule has shown activity in these tests preclinically, then the clinical development process will begin.

Characteristics

The process of cancer drug discovery involves multiple steps, beginning with selection of appropriate cancer targets, complex design and screening of potential molecules, and completion of drug characterization in disease relevant preclinical models to evaluate anticancer efficacy and toxicity tolerance prior to advancing to clinical development. Each step will be discussed in more detail in the following sections.

Cancer Targets

The biology of...

Keywords

Gastrointestinal Stromal Tumor Cancer Drug Cancer Target Brentuximab Vedotin Preclinical Tumor Model 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–673CrossRefPubMedGoogle Scholar
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  3. Mariotto AB, Rowland JH, Yabroff KR, Scoppa S, Hachey M, Ries L, Feuer EJ (2009) Long-term survivors of childhood cancers in the United States. Cancer Epidemiol Biomarkers Prev 18:1033–1040CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Oncology ResearchPfizer Worldwide R&DSan DiegoUSA