Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Transplacental Carcinogenesis

  • Mark Steven Miller
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7079-2

Synonyms

Definition

Transplacental carcinogenesis is a subfield of cancer research that looks at the effects of exposure of the fetus to chemical and physical agents that may cause cancer. The best known example of a chemical administered during pregnancy that resulted in tumors in the children of the treated mothers is diethylstilbestrol (DES). Young women of mothers who were treated during pregnancy with DES exhibited an increased incidence of vaginal cancer (Miyagawa et al. 2011). The best known example of a physical agent that resulted in cancer in the offspring of exposed mothers is radiation. Studies from the survivors of the atomic bomb blasts in Japan showed that exposure of the fetus to radiation caused increased incidences of cancer at several organ sites (Pierce and Preston 2000).

Characteristics

Types of Transplacental Carcinogens

Studies conducted in the field of transplacental carcinogenesis...

Keywords

Physical Agent Atomic Bomb Pregnant Mother Environmental Toxin Nonpolar Compound 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Cancer Biology, Comprehensive Cancer CenterWake Forest School of MedicineWinston-SalemUSA