Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Kamaleshwar Singh
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7078-7



Methyltransferases (MTases) are a family of enzymes that catalyze the transfer of a methyl group from a donor to an acceptor. Methyltransferases are found in both prokaryotes and eukaryotes; however, their structure and function are different. Based on the substrate for methylation, the two well-known types of methyltransferases in vertebrates are DNA methyltransferase (DNMTases) and histone methyltransferase (HMTases). Besides the DNMTases and HMTases, there is another class of MTases that catalyzes the transfer of methyl group to the 5-prime-terminal guanosine of pre-mRNA, known as RNA MTases.



Depending on bases and the position of its carbon in DNA on which the DNMTases catalyze the transfer of methyl group, DNMTases can be divided into three different groups:
  • N-6 adenine-specific DNA methylase (A-MTase): This class of enzymes known as m6A methyltransferases, specifically methylates the amino group at the C-6 position of...


Histone Methyltransferases Early Embryogenesis Stage Host Restriction Enzyme 
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© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.The Institute of Environmental and Human Health (TIEHH)Texas Tech UniversityLubbockUSA