Methyltransferases (MTases) are a family of enzymes that catalyze the transfer of a methyl group from a donor to an acceptor. Methyltransferases are found in both prokaryotes and eukaryotes; however, their structure and function are different. Based on the substrate for methylation, the two well-known types of methyltransferases in vertebrates are DNA methyltransferase (DNMTases) and histone methyltransferase (HMTases). Besides the DNMTases and HMTases, there is another class of MTases that catalyzes the transfer of methyl group to the 5-prime-terminal guanosine of pre-mRNA, known as RNA MTases.
N-6 adenine-specific DNA methylase (A-MTase): This class of enzymes known as m6A methyltransferases, specifically methylates the amino group at the C-6 position of...