Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Lipocalin

  • Frank Thévenod
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7077-4

Definition

Lipocalins are extracellular proteins that are secreted by cells; they were initially characterized as shuttle and transporter proteins. But it is now well established that members of the lipocalin family perform a variety of important functions by virtue of multiple molecular interactions underlying common molecular-recognition properties: binding to small hydrophobic molecules, binding to specific cell-surface receptors (e.g., plasma retinol-binding protein (RBP4) receptor STRA6, megalin, or lipocalin-2 receptor), and complexation with soluble macromolecules by non-covalent association or covalent link (Flower 1996).

Characteristics

The lipocalin family comprises a group of over 20 small (160–180 amino acid residues) glycoproteins. Most human lipocalins are clustered on the long arm of chromosome 9. Lipocalins exhibit only limited primary amino acid sequence similarity but share a highly conserved tertiary structure and several common sequence motifs. Their core structure...

Keywords

Chronic Myeloid Leukemia Chronic Myeloid Leukemia Cell Free Arachidonic Acid Lipocalin Family RBP4 Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Flower DR (1996) The lipocalin protein family: structure and function. Biochem J 318(Pt 1):1–14PubMedCentralPubMedGoogle Scholar
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  3. Seppälä M, Koistinen H, Koistinen R, Hautala L, Chiu PC, Yeung WS (2009) Glycodelin in reproductive endocrinology and hormone-related cancer. Eur J Endocrinol 160(2):121–133PubMedCrossRefGoogle Scholar
  4. Søiland H, Søreide K, Janssen EA, Körner H, Baak JP, Søreide JA (2007) Emerging concepts of apolipoprotein D with possible implications for breast cancer. Cell Oncol 29(3):195–209PubMedGoogle Scholar
  5. Yang J, Moses MA (2009) Lipocalin 2: a multifaceted modulator of human cancer. Cell Cycle 8(15):2347–2352PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Private Universität Witten/Herdecke gGmbHWittenGermany