Living reference work entry
The ATP-binding cassette transporters from the sub-family C (encoded by ABCC genes) are plasma membrane ATP-dependent efflux transporters with broad substrate specificity for endogenous and xenobiotic anionic substances.
Members and Functional Properties
The human ABCC subfamily of transporters contains 13 members from the ATP binding cassette (ABC) superfamily with sizes from 1,325 to 1,545 amino acids. The ABCC subfamily includes the cystic fibrosis transmembrane conductance regulator (CFTR, ABCC7), two sulfonylurea receptors SUR1 (ABCC8) and SUR2A/B (ABCC9), and nine MRPs. ABCC proteins are energy-dependent transporters, except for CFTR which acts as channel gated by ATP binding and hydrolysis, and SURs which act as ATP-dependent potassium channel regulators. All ABCC proteins share structural features in their nucleotide binding domains (NBDs) that...
KeywordsCystic Fibrosis Transmembrane Conductance Regulator Cytosine Arabinoside Small Cell Lung Cancer Cell Estrone Sulfate ABCC Protein
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© Springer-Verlag Berlin Heidelberg (outside the USA) 2012