Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

ABCC Transporters

  • Rodrigo Franco
  • Laura Zavala-Flores
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7076-2

Synonyms

Definition

The ATP-binding cassette transporters from the sub-family C (encoded by ABCC genes) are plasma membrane ATP-dependent efflux transporters with broad substrate specificity for endogenous and xenobiotic anionic substances.

Characteristics

Members and Functional Properties

The human ABCC subfamily of transporters contains 13 members from the ATP binding cassette (ABC) superfamily with sizes from 1,325 to 1,545 amino acids. The ABCC subfamily includes the cystic fibrosis transmembrane conductance regulator (CFTR, ABCC7), two sulfonylurea receptors SUR1 (ABCC8) and SUR2A/B (ABCC9), and nine MRPs. ABCC proteins are energy-dependent transporters, except for CFTR which acts as channel gated by ATP binding and hydrolysis, and SURs which act as ATP-dependent potassium channel regulators. All ABCC proteins share structural features in their nucleotide binding domains (NBDs) that...

Keywords

Cystic Fibrosis Transmembrane Conductance Regulator Cytosine Arabinoside Small Cell Lung Cancer Cell Estrone Sulfate ABCC Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

References

  1. Chen ZS, Tiwari AK (2011) Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases. FEBS J 278(18):3226–3245PubMedCentralCrossRefPubMedGoogle Scholar
  2. Deeley RG, Westlake C, Cole SP (2006) Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Physiol Rev 86(3):849–899CrossRefPubMedGoogle Scholar
  3. Franco R, Cidlowski JA (2009) Apoptosis and glutathione: beyond an antioxidant. Cell Death Differ 16(10):1303–1314CrossRefPubMedGoogle Scholar
  4. Gillet JP, Gottesman MM (2010) Mechanisms of multidrug resistance in cancer. Methods Mol Biol 596:47–76CrossRefPubMedGoogle Scholar
  5. Keppler D (2011) Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy. Handb Exp Pharmacol 201:299–323CrossRefPubMedGoogle Scholar
  6. Li Y, Sun Z, Wu Y, Babovic-Vuksanovic D, Li Y, Cunningham JM, Pankratz VS, Yang P (2010) Cystic fibrosis transmembrane conductance regulator gene mutation and lung cancer risk. Lung Cancer 70(1):14–21PubMedCentralCrossRefPubMedGoogle Scholar
  7. Qian X, Li J, Ding J, Wang Z, Duan L, Hu G (2008) Glibenclamide exerts an antitumor activity through reactive oxygen species-c-jun NH2-terminal kinase pathway in human gastric cancer cell line MGC-803. Biochem Pharmacol 76(12):1705–1715CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg (outside the USA) 2012

Authors and Affiliations

  1. 1.Redox Biology Center, School of Veterinary Medicine and Biomedical SciencesUniversity of Nebraska-LincolnLincolnUSA