Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Antimitotic Drugs

  • Hassan Bousbaa
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7074-1

Definition

Antimitotic drugs inhibit mitosis (cell division). Mitosis is crucial for proliferation and propagation through the body of cancer cells. In this regard, antimitotic drugs are viewed as valuable anticancer agents as they restrict cancer growth and spread.

Characteristics

What are the Current Antimitotic Drugs in Clinical Use to Treat Cancer?

The antimitotic drugs with a proven history of clinical efficacy as anticancer agents are those that affect microtubule dynamics such as the taxanes and vinca alkaloids. Taxanes include paclitaxel and docetaxel which are microtubule-stabilizing agents and are used in clinical treatment of a wide range of cancers such as advanced breast, non-small cell lung, androgen-independent prostate, and ovarian cancers. Vinca alkaloids include vinblastine, vincristine, and vinorelbine which are microtubule-destabilizing agents that have shown antitumor activity in Hodgkin and non-Hodgkin lymphoma, Kaposi sarcoma, acute leukemias, neuroblastoma,...

Keywords

Mitotic Spindle Vinca Alkaloid Aurora Kinase Spindle Assembly Checkpoint Tubulin Subunit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Instituto Investigação Formação Avançada Ciências Tecnologias SaúdeCESPU – Cooperativa de Ensino Superior Politecnico e UniversitarioGandra PRDPortugal