Antimitotic drugs inhibit mitosis (cell division). Mitosis is crucial for proliferation and propagation through the body of cancer cells. In this regard, antimitotic drugs are viewed as valuable anticancer agents as they restrict cancer growth and spread.
What are the Current Antimitotic Drugs in Clinical Use to Treat Cancer?
The antimitotic drugs with a proven history of clinical efficacy as anticancer agents are those that affect microtubule dynamics such as the taxanes and vinca alkaloids. Taxanes include paclitaxel and docetaxel which are microtubule-stabilizing agents and are used in clinical treatment of a wide range of cancers such as advanced breast, non-small cell lung, androgen-independent prostate, and ovarian cancers. Vinca alkaloids include vinblastine, vincristine, and vinorelbine which are microtubule-destabilizing agents that have shown antitumor activity in Hodgkin and non-Hodgkin lymphoma, Kaposi sarcoma, acute leukemias, neuroblastoma,...