Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

AIDS-Associated Malignancies

  • Enrique Mesri
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7073-3

Synonyms

Definition

Cancers that are increased in individuals infected with human immunodeficiency virus (HIV). The most common are Kaposi sarcoma and a subset of B-cell lymphomas (non-Hodgkin lymphomas). Other AIDS-associated malignancies are Hodgkin disease and cancers of the cervix, anus, lung, and the gastrointestinal tract.

Characteristics

At the beginning of the HIV epidemic, the occurrence of certain cancers was considered as a milestone marking the transition to acquired immunosuppression syndrome (AIDS) in HIV infected individuals (Boshoff and Weiss 2002; Grulich et al. 2007). Those were Kaposi sarcoma (KS, AIDS-KS), non-Hodgkin lymphomas (NHL, AIDS-NHL), and invasive cervical cancers (Boshoff and Weiss 2002; Grulich et al. 2007; Cavallin et al. 2014). The incidence of HIV-associated cancers have been greatly reduced in the...

Keywords

Human Immunodeficiency Virus Epstein Barr Virus Human Immunodeficiency Virus Infection Oncogenic Virus Primary Effusion Lymphoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Boshoff C, Weiss R (2002) AIDS-related malignancies. Nat Rev Cancer 2:373–382. http://www.ncbi.nlm.nih.gov/pubmed/12044013 CrossRefPubMedGoogle Scholar
  2. Casper C (2011) The increasing burden of HIV-associated malignancies in resource-limited regions. Annu Rev Med 62:157–170. http://www.ncbi.nlm.nih.gov/pubmed/20868276 CrossRefPubMedGoogle Scholar
  3. Cavallin LE, Goldschmidt-Clermont P, Mesri EA (2014) Molecular and cellular mechanisms of KSHV oncogenesis of Kaposi’s sarcoma associated with HIV/AIDS. PLoS Pathog. 10:e1004154. http://www.ncbi.nlm.nih.gov/pubmed/25010730 CrossRefPubMedPubMedCentralGoogle Scholar
  4. Cesarman E, Mesri EA (1999) Virus-associated lymphomas. Curr Opin Oncol 11:322–332. http://www.ncbi.nlm.nih.gov/pubmed/10505767 CrossRefPubMedGoogle Scholar
  5. Grulich AE, van Leeuwen MT, Falster MO, Vajdic CM (2007) Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet 370:59–67. http://www.ncbi.nlm.nih.gov/pubmed/17617273 CrossRefPubMedGoogle Scholar
  6. Mesri EA, Cesarman E, Boshoff C (2010) Kaposi sarcoma and its associated herpesvirus. Nat Rev Cancer 10:707–719. http://www.ncbi.nlm.nih.gov/pubmed/20865011 CrossRefPubMedPubMedCentralGoogle Scholar
  7. Mesri EA, Feitelson MA, Munger K (2014) Human viral oncogenesis: a cancer hallmarks analysis. Cell Host Microbe 15:266-82. http://www.ncbi.nlm.nih.gov/pubmed/24629334 CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Viral Oncology Program, Sylvester Comprehensive Cancer Center and Development Center for AIDS Research, Department of Microbiology and ImmunologyUniversity of Miami Miller School of MedicineMiamiUSA