Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Hirota FujikiEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7069-3


Cyanobacterial hepatotoxin, a potent tumor promoter; there are three forms of microcystins:
  • Microcystin-LR is cyclo(-D-Ala-L-Leu-D-erythro-beta methylisoaspartic acid-(Masp)- L-Arg-(2S,3S,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-(4E,6E)-dienoic acid (Adda)-D-isoGlu-N-methyldehydroalanine (Mdha)-).

  • Microcystin-YR (microcystin containing tyrosine instead of the leucine in microcystin-LR).

  • Microcystin-RR (microcystin containing arginine instead of the leucine in microcystin-LR) (Fig. 1a).


Protein Phosphatase Okadaic Acid Microcystis Aeruginosa Round Form Primary Human Fibroblast 
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© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Clinical Laboratory Medicine, Faculty of MedicineSaga UniversitySaga 849-8501Japan