Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Microcystin-LR

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7069-3

Definition

Cyanobacterial hepatotoxin, a potent tumor promoter; there are three forms of microcystins:
  • Microcystin-LR is cyclo(-D-Ala-L-Leu-D-erythro-beta methylisoaspartic acid-(Masp)- L-Arg-(2S,3S,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-(4E,6E)-dienoic acid (Adda)-D-isoGlu-N-methyldehydroalanine (Mdha)-).

  • Microcystin-YR (microcystin containing tyrosine instead of the leucine in microcystin-LR).

  • Microcystin-RR (microcystin containing arginine instead of the leucine in microcystin-LR) (Fig. 1a).

Keywords

Protein Phosphatase Okadaic Acid Microcystis Aeruginosa Round Form Primary Human Fibroblast 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Clinical Laboratory Medicine, Faculty of MedicineSaga UniversitySaga 849-8501Japan