Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Hendrik Fuchs
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7065-6


Saporin is a ribosome-inactivating protein (RIP) from the common soapwort (Saponaria officinalis L.). It is an enzyme that releases a particular adenine from the 28S ribosomal RNA of eukaryotic ribosomes (at position 4324 referred to rat) and thus inactivates protein biosynthesis. Saporin is a type-I-RIP, which means that it consists only of one protein chain, the A-chain, representing catalytic activity, whereas type-II-RIPs contain in addition a cell-binding domain, the B-chain. Saporin is used in a number of attempts as part of targeted toxins in cancer therapy.


Structure and Function

Saporin is a ribosome-inactivating plant protein (RIP) from the common soapwort (Saponaria officinalis L.), a vespertine flower belonging to the carnation family (Caryophyllaceae) (Lombardi et al. 2010). The protein can be isolated from different tissues including leaves, stems, roots, flowers, and fruits. A number of isoforms differing in a couple of amino acids have been...


Mouse Tumor Model Endosomal Escape Eukaryotic Ribosome Tumor Necrosis Factor Receptor Family Dianthus Caryophyllus 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Institute for Laboratory Medicine, Clinical Chemistry and PathobiochemistryCharité – Universitätsmedizin BerlinBerlinGermany