Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Sonal Gupta
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7056-10


Pancreatitis is a disease characterized by the inflammation of exocrine pancreas that is initiated by the premature activation and intracellular release of the digestive enzymes produced in pancreatic acinar cells. The release of these enzymes causes destruction of acinar cells and a subsequent robust inflammatory response, resulting in a significant injury to the pancreas.


Pancreatitis was first described as a disease of autodigestion in 1896 by pathologist Hans Chiari. Common symptoms include searing upper abdominal pain that radiates into the back; nausea and vomiting, especially after eating; fever; rapid heartbeat; and jaundice (the yellowing of the skin, the whites of the eyes (conjunctiva), and mucous membranes caused by increased levels of bilirubin in the blood that may be due to liver damage as well as other diseases) – discoloration is the result of increased levels of bilirubin in the blood due to obstruction of the biliary drainage from the liver...


Pancreatic Cancer Acute Pancreatitis Chronic Pancreatitis Acinar Cell Cystic Fibrosis Transmembrane Conductance Regulator 
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See Also

  1. (2012) Diet. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1109. doi: 10.1007/978-3-642-16483-5_1610Google Scholar
  2. Gooch JW (2011) Discoloration. In: Gooch JW (ed) Encyclopedic Dictionary of Polymers, 2nd edn. Springer New York, p 234. doi: 10.1007/978-1-4419-6247-8_3821Google Scholar
  3. Gooch JW (2011) Yellowing. In: Gooch JW (ed) Encyclopedic Dictionary of Polymers, 2nd edn. Springer New York, p 821. doi: 10.1007/978-1-4419-6247-8_12958Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Pathology, The Sol Goldman Pancreatic Cancer Research CenterJohns Hopkins University School of MedicineBaltimoreUSA