Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Pancreatitis

  • Sonal Gupta
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_7056-10

Definition

Pancreatitis is a disease characterized by the inflammation of exocrine pancreas that is initiated by the premature activation and intracellular release of the digestive enzymes produced in pancreatic acinar cells. The release of these enzymes causes destruction of acinar cells and a subsequent robust inflammatory response, resulting in a significant injury to the pancreas.

Characteristics

Pancreatitis was first described as a disease of autodigestion in 1896 by pathologist Hans Chiari. Common symptoms include searing upper abdominal pain that radiates into the back; nausea and vomiting, especially after eating; fever; rapid heartbeat; and jaundice (the yellowing of the skin, the whites of the eyes (conjunctiva), and mucous membranes caused by increased levels of bilirubin in the blood that may be due to liver damage as well as other diseases) – discoloration is the result of increased levels of bilirubin in the blood due to obstruction of the biliary drainage from the liver...

Keywords

Pancreatic Cancer Acute Pancreatitis Chronic Pancreatitis Acinar Cell Cystic Fibrosis Transmembrane Conductance Regulator 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

References

  1. DiMagno MJ, DiMagno EP (2012) Chronic pancreatitis. Curr Opin Gastroenterol 28:523–531CrossRefPubMedPubMedCentralGoogle Scholar
  2. LaRusch J, Whitcomb DC (2011) Genetics of pancreatitis. Curr Opin Gastroenterol 27:467–474CrossRefPubMedPubMedCentralGoogle Scholar
  3. Momi N, Kaur S, Krishn SR, Batra SK (2012) Discovering the route from inflammation to pancreatic cancer. Minerva Gastroenterol Dietol 58:283–297PubMedPubMedCentralGoogle Scholar
  4. Sah RP, Garg P, Saluja AK (2012) Pathogenic mechanisms of acute pancreatitis. Curr Opin Gastroenterol 28:507–515CrossRefPubMedPubMedCentralGoogle Scholar
  5. Su KH, Cuthbertson C, Christophi C (2006) Review of experimental animal models of acute pancreatitis. HPB (Oxford) 8:264–286CrossRefGoogle Scholar

See Also

  1. (2012) Diet. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1109. doi: 10.1007/978-3-642-16483-5_1610Google Scholar
  2. Gooch JW (2011) Discoloration. In: Gooch JW (ed) Encyclopedic Dictionary of Polymers, 2nd edn. Springer New York, p 234. doi: 10.1007/978-1-4419-6247-8_3821Google Scholar
  3. Gooch JW (2011) Yellowing. In: Gooch JW (ed) Encyclopedic Dictionary of Polymers, 2nd edn. Springer New York, p 821. doi: 10.1007/978-1-4419-6247-8_12958Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Pathology, The Sol Goldman Pancreatic Cancer Research CenterJohns Hopkins University School of MedicineBaltimoreUSA