Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Ovarian Cancer Drug Resistance

  • Maria Paola Costi
  • John A. Green
  • Stefania Ferrari
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6990-5

Synonyms

Definition

Ovarian cancer is responsible for 4 % of deaths from cancer in women. Treatment comprises a combination of surgery and chemotherapy, and around 80 % of ovarian cancer patients initially achieve complete remission after primary treatment. However, the majority will relapse and eventually develop resistance to chemotherapy.

Characteristics

Standard chemotherapy comprises drugs based on the platinum complexes (carboplatin/cisplatin) which are either given as a single agent or in combination with the taxane paclitaxel. The chemotherapeutic activity of platinum drugs is mainly based on their ability to form DNA adducts and in particular the 1,2-d(GpG) intrastrand cross-link. Here, the platinum coordinates the N7 atoms of adjacent guanosines in the DNA strand and is poorly repaired in cells, with persistence of the lesion ultimately interfering with replication and transcription leading to cell death (Fig. 1). Drug resistance is a polygenic...

Keywords

Ovarian Cancer Hepatocyte Growth Factor Epithelial Ovarian Cancer PARP Inhibitor Platinum Drug 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Maria Paola Costi
    • 1
  • John A. Green
    • 2
  • Stefania Ferrari
    • 1
  1. 1.Department of Pharmaceutical SciencesUniversity of Modena and Reggio EmiliaModenaItaly
  2. 2.Department of Cancer MedicineUniversity of LiverpoolLiverpoolUK