Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Abraxas

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6874-2

Definition

BRCA1-A complex subunit Abraxas. Component of the BRCA1-A complex, a complex that specifically recognizes “Lys-63”-linked ubiquitinated (see “Ubiquitination”) histones H2A and gamma-H2AX at DNA damage sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes “Lys-63”-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1. Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.

Cross-References

See Also

  1. (2012) BRCA1. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 481. doi: 10.1007/978-3-642-16483-5_6868Google Scholar
  2. (2012) Double Strand Break. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1156. doi: 10.1007/978-3-642-16483-5_1718Google Scholar
  3. (2012) GammaH2AX. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1494. doi: 10.1007/978-3-642-16483-5_2576Google Scholar
  4. (2012) Histones. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1706. doi: 10.1007/978-3-642-16483-5_2762Google Scholar
  5. (2012) RAP80. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3173. doi: 10.1007/978-3-642-16483-5_6873Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.German Cancer Research Center (DKFZ)HeidelbergGermany