Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Dolores C. García-Olmo
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6870-6



The KRAS gene is the human cellular homologue of a transforming gene isolated from the Kirsten rat sarcoma virus. It belongs to the mammalian RAS gene family, which name derived from “rat sarcoma” and which most studied members are KRAS, HRAS, and NRAS. These genes encode proteins with a molecular mass of 21 kD and the three are homologues of rodent sarcoma virus genes that have transforming abilities.

While these wild-type cellular proteins in humans play a vital role in normal tissue signaling, including proliferation, differentiation, and senescence, mutated genes are potent oncogenes that play an essential role in many human cancers.
  • Approved symbol from the HUGO Gene Nomenclature Committee (HGNC) database: KRAS

  • Previous name: v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homologue. Previous symbol: KRAS2

  • Also known as KRAS1...


Epidermal Growth Factor Receptor Pancreatic Cancer KRAS Mutation Endometrial Adenocarcinoma KRAS Gene 
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© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Unidad de InvestigaciónComplejo Hospitalario Universitario de AlbaceteAlbaceteSpain