Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Robert A. Gardiner
  • Martin F. Lavin
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6847-2


Prostate cancer antigen 3 (nonprotein coding), formerly called differential display code 3 (DDC3), is expressed in prostate cells its overexpression serving as a biomarker for prostate cancer to complement the commonly used serum prostate-specific antigen (PSA). The combination of PCA3 together with other methods of detecting prostate cancer such as serum PSA, DRE, and TRUS biopsy represented an important advance in the early detection of this disease (see “Prostate Cancer Diagnosis”).


Prostate cancer is a tumour in which a biomarker, prostate-specific antigen (PSA), is employed to assist in diagnosis. However, an elevated PSA per se is not a specific enough test for prostate cancer but rather an indicator of its possibility, with histological confirmation usually via transrectal ultrasound (TRUS)-guided biopsy, required.

What has been lacking for prostate cancer is a biomarker of appropriate robustness for detection of the disease and for categorizing...


Prostate Cancer Benign Prostate Hyperplasia Detect Prostate Cancer Normal Prostate Tissue Prostate Cancer Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.University of Queensland Centre for Clinical Research at Royal Brisbane & Women’s HospitalThe University of QueenslandBrisbaneAustralia