Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Prostate Cancer Diagnosis

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_6825-2

Synonyms

Definition

Historically, prostate cancer presented in an advanced form. Usually it was suspected by palpating a hard and irregular gland on digital rectal examination (DRE) and/or by visualizing bone-dense secondary deposits on radiographs (x-rays) with the diagnosis confirmed by microscopic examination of biopsied or resected tissue from a malignant prostate gland. Today, the large majority of cancers are diagnosed at a much earlier stage when the tumor is clinically localized to the prostate gland itself. However, Early Detection of prostate cancer remains contentious because of uncertainty that diagnosis will be of benefit for individual patients. Although adverse outcomes and imprecision with the detection process itself are changing, unwanted effects associated with treatment interventions and the uncertainty that these interventions will prolong and provide an acceptable quality of life persist.

Characteristics...

Keywords

Prostate Cancer Benign Prostate Hyperplasia Active Surveillance Digital Rectal Examination Develop Prostate Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Andriole GL, Bostwick DG, Brawley OW, Gomella LG, Marberger M, Montorsi F, Pettaway CA, Tammela TL, Teloken C, Tindall DJ, Somerville MC, Wilson TH, Fowler IL, Rittmaster RS, REDUCE Study Group (2010) Effect of Dutasteride on the risk of prostate cancer. N Eng J Med 362:1192–1202CrossRefGoogle Scholar
  2. Andriole GL, Crawford ED, Grubb RL 3rd et al (2012) Prostate cancer screening in the randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial: mortality results after 13 years of follow-up. J Natl Cancer Inst 104(2):125–132PubMedPubMedCentralCrossRefGoogle Scholar
  3. Katelaris NC, Bolton DM, Weerakoon M et al (2015) Current role of multiparametric magnetic resonance imaging in the management of prostate cancer. Korean J Urol 56(5):337–345PubMedPubMedCentralCrossRefGoogle Scholar
  4. Roobol MJ, Schröder FH, Crawford ED, Freedland SJ, Sartor AO, Fleshner N, Andriole GL (2009) A framework for the identification of men at increased risk for prostate cancer. J Urol 182:2112–2120PubMedCrossRefGoogle Scholar
  5. Sakr WA, Grignon DJ, Crissman JD, Heilbrun LK, Cassin BJ, Pontes JJ, Haas GP (1994) High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20–69: an autopsy study of 249 cases. In Vivo 8(3):439–443PubMedGoogle Scholar
  6. Schröder FH, Hugosson J, Carlsson S et al (2012) Screening for prostate cancer decreases the risk of developing metastatic disease: findings from the European Randomized Study of Screening for Prostate Cancer (ERSPC). Eur Urol 62(5):745–752PubMedCrossRefGoogle Scholar
  7. Schröder FH, Hugosson J, Roobol MJ et al (2014) Screening and prostate cancer mortality: results of the European Randomised Study of Screening for Prostate Cancer (ERSPC) at 13 years of follow-up. Lancet 384(9959):2027–2035PubMedPubMedCentralCrossRefGoogle Scholar
  8. Thompson IM, Pauler DK, Goodman PJ, Tangen CM, Lucia MS, Parnes HL, Minasian LM, Ford LG, Lippman SM, Crawford ED, Crowley JJ, Coltman CA Jr (2004) Prevalence of prostate cancer among men with a prostate-specific antigen level < or =4.0 ng per milliliter. N Eng J Med 350:2239–2246CrossRefGoogle Scholar
  9. Vertosick EA, Poon BY, Vickers AJ (2014) Relative value of race, family history and prostate specific antigen as indications for early initiation of prostate cancer screening. J Urol 192(3):724–729PubMedPubMedCentralCrossRefGoogle Scholar

See Also

  1. (2012) 5-Alpha reductase. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 147–148. doi:10.1007/978-3-642-16483-5_6815Google Scholar
  2. (2012) Confounding. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 968. doi:10.1007/978-3-642-16483-5_1304Google Scholar
  3. (2012) Dutasteride. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1171. doi:10.1007/978-3-642-16483-5_6814Google Scholar
  4. (2012) Finasteride. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1407. doi:10.1007/978-3-642-16483-5_2191Google Scholar
  5. (2012) PSA. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 3111–3112. doi:10.1007/978-3-642-16483-5_6738Google Scholar
  6. (2012) Transrectal ultrasound. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3775. doi:10.1007/978-3-642-16483-5_6782Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.School of MedicineUniversity of QueenslandBrisbaneAustralia
  2. 2.Centre for Clinical ResearchUniversity of QueenslandHerstonAustralia
  3. 3.Royal Brisbane and Women’s HospitalBrisbaneAustralia
  4. 4.Edith Cowan University Western AustraliaJoondalupAustralia
  5. 5.Department of SurgeryMonash UniversityMelbourneAustralia